Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 2/20 | 0.43 |
| ▸ | CA2 | P00918 | 2/20 | 0.43 |
| ▸ | FFAR3 | O14843 | 3/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LCK | P06239 | 1/20 | 0.31 |
| ▸ | FYN | P06241 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.30 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.30 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.30 |
| ▸ | HTR2A | P28223 | 1/20 | 0.30 |
| ▸ | HTR2C | P28335 | 1/20 | 0.30 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.30 |
| ▸ | HRH1 | P35367 | 1/20 | 0.30 |
| ▸ | DRD3 | P35462 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propane SCHEMBL3519784 | 0.84 | — | — | |
| Bicarbonate SCHEMBL1127897 | 0.80 | FFAR3 (0.58) | CA1CA2FFAR3CA9HDAC1 | |
| Bicarbonate SCHEMBL28363045 | 0.80 | FFAR3 (0.58) | CA1CA2FFAR3CA9HDAC1 | |
| Bicarbonate SCHEMBL10955970 | 0.80 | FFAR3 (0.58) | CA1CA2FFAR3CA9HDAC1 | |
| Bicarbonate SCHEMBL591922 | 0.80 | FFAR3 (0.58) | CA1CA2FFAR3CA9HDAC1 | |
| Bicarbonate SCHEMBL2497150 | 0.80 | FFAR3 (0.58) | CA1CA2FFAR3CA9HDAC1 | |
| Bicarbonate SCHEMBL28893179 | 0.80 | FFAR3 (0.58) | CA1CA2FFAR3CA9HDAC1 | |
| Bicarbonate SCHEMBL7151962 | 0.80 | — | — | |
| Bicarbonate SCHEMBL288699 | 0.80 | FFAR3 (0.58) | CA1CA2FFAR3CA9HDAC1 | |
| Bicarbonate SCHEMBL9637401 | 0.80 | CA1 (0.67) | CA1CA2FFAR3CA9LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1199339-B1 | Water-reducible coating composition for providing corrosion protection | METAL COATINGS INT INC (US) | 2004-12-29 | — | — | EP | claimed |