SCHEMBL68969

SCHEMBL68969

COC(=O)c1ccc2c(c1C(=O)OC)C(=O)c1ccccc1C2=O

nearest known ligand 0.73

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 11/20 0.73
MITF O75030 1/20 0.73
SMN1; SMN2 Q16637 7/20 0.52
MAPK1 P28482 4/20 0.52
KDM4E B2RXH2 2/20 0.52
MMP14 P50281 1/20 0.52
ALDH1A1 P00352 6/20 0.50
NPC1 O15118 4/20 0.50
RAB9A P51151 4/20 0.50
HTT P42858 2/20 0.50
IDO1 P14902 1/20 0.50
TDP1 Q9NUW8 1/20 0.50
PKM P14618 1/20 0.49
MEN1 O00255 6/20 0.49
KMT2A Q03164 6/20 0.49
RECQL P46063 2/20 0.49
LMNA P02545 1/20 0.49
POLB P06746 1/20 0.49
THRB P10828 1/20 0.49
L3MBTL1 Q9Y468 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1415676 0.94 MAPT (0.64) MAPTMITFSMN1; SMN2MAPK1KDM4E
SCHEMBL8941340 0.87 MAPT (0.57) MAPTMITFSMN1; SMN2MAPK1KDM4E
SCHEMBL28318060 0.84 MAPT (0.73) MAPTMITFSMN1; SMN2MAPK1KDM4E
SCHEMBL8941856 0.83 MAPT (0.71) MAPTMITFSMN1; SMN2MAPK1KDM4E
SCHEMBL8757428 0.82 MAPT (0.69) MAPTMITFSMN1; SMN2MAPK1ALDH1A1
SCHEMBL10391553 0.82 MAPT (0.74) MAPTMITFSMN1; SMN2MAPK1KDM4E
SCHEMBL30393962 0.79 MAPT (0.65) MAPTMITFSMN1; SMN2ALDH1A1NPC1
SCHEMBL2879389 0.79 MAPT (0.65) MAPTMITFSMN1; SMN2ALDH1A1NPC1
SCHEMBL4838944 0.78 MAPT (0.60) MAPTMITFSMN1; SMN2MAPK1KDM4E
SCHEMBL69292 0.76 MAPT (0.61) MAPTMITFSMN1; SMN2ALDH1A1NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0713506-B1 A PROCESS FOR PREPARING POLY(ETHYLENE 2,6-NAPHTHALENEDICARBOXYLATE) CONTAINING POLYMER BLENDS HAVING REDUCED FLUORESCENCE EASTMAN CHEM CO (US) 1997-05-07 EP claimed
EP-0713506-A1 A PROCESS FOR PREPARING NAPHTHALENEDICARBOXYLIC ACID CONTAINING POLYMER BLENDS HAVING REDUCED FLUORESCENCE EASTMAN CHEM CO (US) 1996-05-29 EP claimed
US-5391330-A Melt blending aromatic ketone or naphthol compounds EASTMAN CHEMICAL COMPANY (US) 1995-02-21 US claimed
WO-1995004777-A1 A PROCESS FOR PREPARING NAPHTHALENEDICARBOXYLIC ACID CONTAINING POLYMER BLENDS HAVING REDUCED FLUORESCENCE EASTMAN CHEMICAL COMPANY (US) 1995-02-16 WO claimed
EP-2479203-A1 AROMATIC POLYESTER Muroran Institute of Technology (JP) 2012-07-25 EP disclosed
US-20120172570-A1 AROMATIC POLYESTER NITTA CORPORATION 2012-07-05 US disclosed
US-8129493-B2 Aromatic polyester MURORAN INSTITUTE OF TECHNOLOGY (JP) 2012-03-06 US disclosed
US-20110224343-A1 MODIFIER FOR AROMATIC POLYESTER AND AROMATIC POLYESTER RESIN COMPOSITION COMPRISING THE SAME MURORAN INSTITUTE OF TECHNOLOGY (JP) 2011-09-15 US disclosed
US-20110092662-A1 AROMATIC POLYESTER NITTA CORPORATION (JP) 2011-04-21 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110224343-A1 MODIFIER FOR AROMATIC POLYESTER AND AROMATIC POLYESTER RESIN COMPOSITION COMPRISING THE SAME F12, PHAX, WDR82 MAPT 1923/4885MITF 513/4885SMN1; SMN2 4357/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.