SCHEMBL68970

SCHEMBL68970

COC(=O)C1=C(C(=O)OC)c2cc3ccccc3cc2C(=O)C1=O

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FGFR1 P11362 4/20 0.46
FGFR2 P21802 4/20 0.46
FGFR4 P22455 4/20 0.46
FGFR3 P22607 4/20 0.46
SRC P12931 3/20 0.46
SLC6A2 P23975 4/20 0.45
SLC6A3 Q01959 3/20 0.45
SLC6A4 P31645 1/20 0.45
HSP90AA1 P07900 1/20 0.44
PAX8 Q06710 1/20 0.44
ALDH1A1 P00352 4/20 0.42
HPGD P15428 3/20 0.42
KDM4E B2RXH2 3/20 0.42
TSHR P16473 1/20 0.40
GAPDH P04406 1/20 0.40
NPSR1 Q6W5P4 1/20 0.39
MITF O75030 1/20 0.38
MAPT P10636 1/20 0.38
ALPL P05186 1/20 0.38
PLAU P00749 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL68629 0.75 PTPRC (0.46) FGFR1FGFR2FGFR4FGFR3ALDH1A1
SCHEMBL19230417 0.71 ALDH1A1 (0.52) ALDH1A1HPGDKDM4ETSHRGAPDH
SCHEMBL68218 0.70 KDM4E (0.61) SLC6A2SLC6A3SLC6A4HSP90AA1PAX8
SCHEMBL29438041 0.70 KDM4E (0.61) SLC6A2SLC6A3SLC6A4HSP90AA1PAX8
SCHEMBL10865211 0.70 MAPT (0.67) ALDH1A1HPGDKDM4EGAPDHNPSR1
SCHEMBL9240488 0.69 TDP1 (0.48) SLC6A2SLC6A3SLC6A4ALDH1A1HPGD
SCHEMBL10698136 0.69 FGFR1 (0.57) FGFR1FGFR2FGFR4FGFR3SRC
SCHEMBL71119 0.69 FGFR1 (0.50) FGFR1FGFR2FGFR4FGFR3SRC
SCHEMBL9242569 0.69 NPSR1 (0.46) FGFR1FGFR2FGFR4FGFR3SRC
SCHEMBL354514 0.69 MEN1 (0.56) ALDH1A1HPGDKDM4ETSHRGAPDH

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2479203-A1 AROMATIC POLYESTER Muroran Institute of Technology (JP) 2012-07-25 EP disclosed
US-20120172570-A1 AROMATIC POLYESTER NITTA CORPORATION 2012-07-05 US disclosed
US-8129493-B2 Aromatic polyester MURORAN INSTITUTE OF TECHNOLOGY (JP) 2012-03-06 US disclosed
US-20110224343-A1 MODIFIER FOR AROMATIC POLYESTER AND AROMATIC POLYESTER RESIN COMPOSITION COMPRISING THE SAME MURORAN INSTITUTE OF TECHNOLOGY (JP) 2011-09-15 US disclosed
US-20110092662-A1 AROMATIC POLYESTER NITTA CORPORATION (JP) 2011-04-21 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110224343-A1 MODIFIER FOR AROMATIC POLYESTER AND AROMATIC POLYESTER RESIN COMPOSITION COMPRISING THE SAME F12, PHAX, WDR82 FGFR1 506/4885FGFR2 695/4885FGFR4 557/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.