Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | FFAR4 | Q5NUL3 | 6/20 | 0.51 |
| ▸ | FFAR1 | O14842 | 5/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14257320 | 0.92 | TSHR (0.60) | MRGPRX4FFAR4FFAR1TSHRL3MBTL1 | |
| SCHEMBL1520326 | 0.83 | LMNA (0.51) | LMNAFFAR4FFAR1TSHRL3MBTL1 | |
| SCHEMBL7824774 | 0.83 | PKM (0.66) | MRGPRX4L3MBTL1PKMNOTUM | |
| SCHEMBL3724645 | 0.83 | TSHR (0.66) | MRGPRX4LMNAFFAR4FFAR1TSHR | |
| SCHEMBL13527395 | 0.83 | KDM4E (0.49) | MRGPRX4LMNAFFAR4FFAR1TSHR | |
| SCHEMBL21653636 | 0.82 | MRGPRX4 (0.49) | MRGPRX4TSHRL3MBTL1NOTUMKDM4E | |
| SCHEMBL27535566 | 0.82 | MCL1 (0.53) | LMNAFFAR4FFAR1TSHRMCL1 | |
| SCHEMBL21596055 | 0.81 | MRGPRX4 (0.51) | MRGPRX4NOTUMKDM4E | |
| SCHEMBL23677886 | 0.81 | MRGPRX4 (0.51) | MRGPRX4L3MBTL1NOTUMKDM4ETP53 | |
| SCHEMBL21653635 | 0.81 | MRGPRX4 (0.48) | MRGPRX4L3MBTL1NOTUMKDM4ETP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2509950-B1 | 5-Amino-4-hydroxypentoyl amides | JANSSEN R & D IRELAND (IE) | 2015-02-25 | — | — | EP | disclosed |
| US-20120295920-A1 | 5-AMINO-4-HYDROXYPENTOYL AMIDES | JANSSEN SCIENCES IRELAND UC (IE) | 2012-11-22 | — | — | US | disclosed |
| US-20120295920-A1 | 5-AMINO-4-HYDROXYPENTOYL AMIDES | JANSSEN SCIENCES IRELAND UC (IE) | 2012-11-22 | — | — | US | disclosed |
| WO-2011070131-A1 | 5-AMINO- 4-HYDROXYPENTOYL AMIDES | TIBOTEC PHARMACEUTICALS (IE) | 2011-06-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120295920-A1 | 5-AMINO-4-HYDROXYPENTOYL AMIDES | C1S, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, H1-10 | MRGPRX4 1014/4885LMNA 1196/4885FFAR4 4270/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.