Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.44 |
| ▸ | USP7 | Q93009 | 2/20 | 0.41 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | PLG | P00747 | 3/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.34 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.34 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.33 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.33 |
| ▸ | PLAT | P00750 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | BCHE | P06276 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Piperidine SCHEMBL2494101 | 0.87 | HRH4 (0.38) | HRH4USP7HRH3 | |
| SCHEMBL2202748 | 0.85 | — | — | |
| SCHEMBL5660853 | 0.81 | — | — | |
| SCHEMBL16992452 | 0.68 | SLC18A3 (0.41) | HRH4USP7SLC18A3SIGMAR1HRH3 | |
| SCHEMBL3635390 | 0.66 | — | — | |
| SCHEMBL16400229 | 0.65 | USP7 (0.53) | HRH4USP7SLC18A3SIGMAR1HRH3 | |
| SCHEMBL7447247 | 0.65 | HRH4 (0.42) | HRH4USP7SLC18A3SIGMAR1HRH3 | |
| SCHEMBL4407368 | 0.65 | CYP2D6 (0.41) | SLC18A3HRH3 | |
| SCHEMBL6237485 | 0.63 | — | — | |
| SCHEMBL20037971 | 0.63 | HRH4 (0.40) | HRH4USP7SLC18A3SIGMAR1HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116178361-A | Preparation of piperidine bisoxadiazole and piperidine amino thiazole substituted antitumor curcumenol derivatives and application thereof in antitumor | 华东理工大学 | 2023-05-30 | — | — | CN | disclosed |
| EP-1951718-B9 | 4-OXADIAZOLYL-PIPERIDINE COMPOUNDS AND USE THEREOF | PURDUE PHARMA LP (US) | 2012-08-15 | — | — | EP | disclosed |
| EP-1951718-B9 | 4-OXADIAZOLYL-PIPERIDINE COMPOUNDS AND USE THEREOF | PURDUE PHARMA LP (US) | 2012-08-15 | — | — | EP | disclosed |
| EP-1951718-B1 | 4-OXADIAZOLYL-PIPERIDINE COMPOUNDS AND USE THEREOF | PURDUE PHARMA LP (US) | 2012-02-29 | — | — | EP | disclosed |
| EP-1951718-B1 | 4-OXADIAZOLYL-PIPERIDINE COMPOUNDS AND USE THEREOF | PURDUE PHARMA LP (US) | 2012-02-29 | — | — | EP | disclosed |
| EP-2298764-A1 | 4-Oxadiazolyl-piperidine compounds and use thereof | Purdue Pharma LP (US) | 2011-03-23 | — | — | EP | disclosed |
| EP-2298764-A1 | 4-Oxadiazolyl-piperidine compounds and use thereof | Purdue Pharma LP (US) | 2011-03-23 | — | — | EP | disclosed |
| EP-2298765-A1 | 4-Oxadiazolyl-piperidine compounds and use thereof | Purdue Pharma LP (US) | 2011-03-23 | — | — | EP | disclosed |
| EP-2298765-A1 | 4-Oxadiazolyl-piperidine compounds and use thereof | Purdue Pharma LP (US) | 2011-03-23 | — | — | EP | disclosed |
| EP-2298765-A1 | 4-Oxadiazolyl-piperidine compounds and use thereof | Purdue Pharma LP (US) | 2011-03-23 | — | — | EP | disclosed |
| US-20080319020-A1 | 4-Oxadiazolyl-Piperidine Compounds and Use Thereof | PURDUE PHARMA L.P. | 2008-12-25 | — | — | US | disclosed |
| US-20080319020-A1 | 4-Oxadiazolyl-Piperidine Compounds and Use Thereof | PURDUE PHARMA L.P. | 2008-12-25 | — | — | US | disclosed |
| CN-101312964-A | 4-oxadiazolyl piperidine compound and use thereof | PURDUE PHARMA LP (US) | 2008-11-26 | — | — | CN | disclosed |
| CN-101312964-A | 4-oxadiazolyl piperidine compound and use thereof | PURDUE PHARMA LP (US) | 2008-11-26 | — | — | CN | disclosed |
| EP-1951718-A1 | 4-OXADIAZOLYL-PIPERIDINE COMPOUNDS AND USE THEREOF | Purdue Pharma LP (US) | 2008-08-06 | — | — | EP | disclosed |
| EP-1951718-A1 | 4-OXADIAZOLYL-PIPERIDINE COMPOUNDS AND USE THEREOF | Purdue Pharma LP (US) | 2008-08-06 | — | — | EP | disclosed |
| EP-1896463-A2 | NOVEL OXADIAZOLE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | ADDEX Pharma S.A. (CH) | 2008-03-12 | — | — | EP | disclosed |
| WO-2007057229-A1 | 4-OXADIAZOLYL-PIPERIDINE COMPOUNDS AND USE THEREOF | PURDUE PHARMA L.P. (US) | 2007-05-24 | — | — | WO | disclosed |
| WO-2007057229-A1 | 4-OXADIAZOLYL-PIPERIDINE COMPOUNDS AND USE THEREOF | PURDUE PHARMA L.P. (US) | 2007-05-24 | — | — | WO | disclosed |
| WO-2006123249-A2 | NOVEL OXADIAZOLE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | ADDEX PHARMA SA (CH) | 2006-11-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080319020-A1 | 4-Oxadiazolyl-Piperidine Compounds and Use Thereof | VIP, ALPI, OPRD1 | HRH4 158/4885USP7 3786/4885SLC18A3 2493/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.