Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 8/20 | 0.52 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.43 |
| ▸ | RHEB | Q15382 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6902224 | 0.85 | CCR2 (0.67) | CCR2PIK3C2BLMNAMAPTALDH1A1 | |
| SCHEMBL5220337 | 0.81 | CCR2 (0.58) | CCR2LMNAMAPTALDH1A1CYP1A2 | |
| SCHEMBL5215970 | 0.73 | CCR2 (0.50) | CCR2LMNAMAPTALDH1A1CYP1A2 | |
| SCHEMBL5215724 | 0.71 | CCR2 (0.50) | CCR2PIK3C2BLMNAMAPTALDH1A1 | |
| SCHEMBL5219974 | 0.71 | CCR2 (0.63) | CCR2PIK3C2BLMNAMAPTALDH1A1 | |
| SCHEMBL30449382 | 0.70 | HDAC6 (0.61) | — | |
| SCHEMBL5213478 | 0.70 | CCR2 (0.64) | CCR2LMNAMAPTALDH1A1CYP1A2 | |
| SCHEMBL5213680 | 0.69 | CCR2 (0.65) | CCR2LMNAMAPTALDH1A1CYP1A2 | |
| SCHEMBL6307042 | 0.69 | CCR2 (0.77) | CCR2LMNAMAPTALDH1A1CYP1A2 | |
| SCHEMBL6599738 | 0.68 | CCR2 (1.00) | CCR2LMNAMAPTALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6833387-B1 | 3-substituted indoles; inhibition of monocyte chemoattractant protein-1 and/or RANTES induced chemotaxis; inflammatory diseases | ASTRAZENECA AB (SE) | 2004-12-21 | — | — | US | disclosed |
| EP-1173421-A2 | INDOLE DERIVATIVES AS ANTI-INFLAMMATION AGENTS | AstraZeneca AB (SE) | 2002-01-23 | — | — | EP | disclosed |
| WO-2000046199-A2 | INDOLE DERIVATIVES AS ANTI-INFLAMMATION AGENTS | ASTRAZENECA AB (SE) | 2000-08-10 | — | — | WO | disclosed |