Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 12/20 | 0.67 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.51 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | PRKDC | P78527 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6899592 | 0.85 | CCR2 (0.52) | CCR2PIK3C2BABCB11ALDH1A1LMNA | |
| SCHEMBL30449382 | 0.83 | HDAC6 (0.61) | — | |
| SCHEMBL5219974 | 0.82 | CCR2 (0.63) | CCR2PIK3C2BABCB11ALDH1A1LMNA | |
| SCHEMBL6599738 | 0.81 | CCR2 (1.00) | CCR2ABCB11ALDH1A1LMNACYP1A2 | |
| SCHEMBL6302591 | 0.79 | CCR2 (1.00) | CCR2ABCB11ALDH1A1LMNACYP1A2 | |
| SCHEMBL5213947 | 0.78 | CCR2 (0.77) | CCR2ABCB11ALDH1A1LMNACYP1A2 | |
| SCHEMBL6307042 | 0.78 | CCR2 (0.77) | CCR2ABCB11ALDH1A1LMNACYP1A2 | |
| SCHEMBL6307834 | 0.77 | CCR2 (0.84) | CCR2ABCB11ALDH1A1LMNACYP1A2 | |
| SCHEMBL5221748 | 0.77 | CCR2 (0.74) | CCR2ABCB11ALDH1A1LMNACYP1A2 | |
| SCHEMBL5214630 | 0.75 | CCR2 (0.80) | CCR2ABCB11ALDH1A1LMNACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6833387-B1 | 3-substituted indoles; inhibition of monocyte chemoattractant protein-1 and/or RANTES induced chemotaxis; inflammatory diseases | ASTRAZENECA AB (SE) | 2004-12-21 | — | — | US | disclosed |