Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 2/20 | 0.42 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 4/20 | 0.40 |
| ▸ | MAOA | P21397 | 3/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.39 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.39 |
| ▸ | FEN1 | P39748 | 1/20 | 0.39 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6895193 | 0.91 | POLB (0.39) | F10POLBMAOBMAOAP2RX7 | |
| SCHEMBL6897569 | 0.91 | MAPT (0.40) | F10POLBMAOBMAOAP2RX7 | |
| SCHEMBL6889569 | 0.89 | MAPK8 (0.43) | PLA2G2APOLBMAPK8MAPTMTNR1A | |
| SCHEMBL6897629 | 0.88 | POLB (0.36) | F10POLBMAOBMAOAP2RX7 | |
| SCHEMBL6690384 | 0.87 | MAPT (0.52) | F10PLA2G2ALMNATSHRPOLB | |
| SCHEMBL5210919 | 0.87 | PLA2G2A (0.52) | PLA2G2ALMNATSHRMAPTTHRB | |
| SCHEMBL6689284 | 0.86 | L3MBTL1 (0.49) | F10PLA2G2ALMNATSHRPOLB | |
| SCHEMBL6694412 | 0.86 | PLA2G2A (0.56) | F10PLA2G2APOLBMAPTTHRB | |
| SCHEMBL6691704 | 0.86 | F10 (0.42) | F10PLA2G2ALMNATSHRPOLB | |
| SCHEMBL6897098 | 0.86 | CYP19A1 (0.44) | PLA2G2APOLBP2RX7MAPK8MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6713645-B1 | INHIBITING SPLA2 MEDIATED RELEASE OF FATTY ACIDS FOR TREATMENT OF CONDITIONS SUCH AS SEPTIC SHOCK | ELI LILLY AND COMPANY | 2004-03-30 | — | — | US | disclosed |
| US-6177440-B1 | THERAPY FOR SEPSIS SHOCK; PHOSPHOLIPASE INHBITOR | ELI LILLY AND COMPANY | 2001-01-23 | — | — | US | disclosed |
| EP-0952149-A2 | Substituted carbazoles, process for their preparation and their use as sPLA2 inhibitiors | ELI LILLY AND COMPANY (US) | 1999-10-27 | — | — | EP | disclosed |