Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 8/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.42 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | AR | P10275 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.38 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.38 |
| ▸ | CFTR | P13569 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6896588 | 0.92 | PLA2G2A (0.44) | MAPK8ARALDH1A1GAAMAPT | |
| SCHEMBL6694644 | 0.92 | AR (0.45) | MAPK8MTNR1AMTNR1BARALDH1A1 | |
| SCHEMBL6897098 | 0.92 | CYP19A1 (0.44) | MAPK8CYP19A1POLBMAPTPLA2G2A | |
| SCHEMBL6898378 | 0.89 | ACMSD (0.39) | MAPK8ARALDH1A1GAAMAPT | |
| SCHEMBL6885056 | 0.89 | MAPT (0.46) | MAPK8POLBARALDH1A1GAA | |
| SCHEMBL6899653 | 0.89 | F10 (0.42) | MAPK8MTNR1AMTNR1BPOLBMAPT | |
| SCHEMBL6893709 | 0.88 | MAPT (0.47) | POLBARALDH1A1GAAMAPT | |
| SCHEMBL6897173 | 0.88 | MAPT (0.44) | POLBGAAMAPT | |
| SCHEMBL6895193 | 0.88 | POLB (0.39) | MAPK8MTNR1AMTNR1BPOLBGAA | |
| SCHEMBL6897569 | 0.88 | MAPT (0.40) | MAPK8POLBALDH1A1GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6713645-B1 | INHIBITING SPLA2 MEDIATED RELEASE OF FATTY ACIDS FOR TREATMENT OF CONDITIONS SUCH AS SEPTIC SHOCK | ELI LILLY AND COMPANY | 2004-03-30 | — | — | US | disclosed |
| US-6177440-B1 | THERAPY FOR SEPSIS SHOCK; PHOSPHOLIPASE INHBITOR | ELI LILLY AND COMPANY | 2001-01-23 | — | — | US | disclosed |
| EP-0952149-A2 | Substituted carbazoles, process for their preparation and their use as sPLA2 inhibitiors | ELI LILLY AND COMPANY (US) | 1999-10-27 | — | — | EP | disclosed |