Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Phenothiazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOX1 | Q9Y5S8 | 9/20 | 0.69 |
| ▸ | GAA | P10253 | 7/20 | 0.69 |
| ▸ | MAPT | P10636 | 7/20 | 0.69 |
| ▸ | MEN1 | O00255 | 5/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.69 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.69 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.69 |
| ▸ | HTT | P42858 | 2/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.69 |
| ▸ | LMNA | P02545 | 2/20 | 0.69 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.69 |
| ▸ | SNCA | P37840 | 3/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | BCHE | P06276 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.57 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.57 |
| ▸ | MAOA | P21397 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phenothiazine SCHEMBL7768973 | 0.86 | NOX1 (0.77) | NOX1GAAMAPTMEN1KMT2A | |
| Phenothiazine SCHEMBL27756460 | 0.84 | NOX1 (0.74) | NOX1GAAMAPTMEN1KMT2A | |
| SCHEMBL4080414 | 0.81 | NOX1 (1.00) | NOX1GAAMAPTMEN1KMT2A | |
| Phenothiazine SCHEMBL9074312 | 0.81 | NOX1 (1.00) | NOX1GAAMAPTMEN1KMT2A | |
| SCHEMBL239600 | 0.81 | NOX1 (1.00) | NOX1GAAMAPTMEN1KMT2A | |
| Benzene SCHEMBL29242182 | 0.80 | NOX1 (0.97) | NOX1GAAMAPTMEN1KMT2A | |
| Phenothiazine SCHEMBL22584033 | 0.80 | NOX1 (0.74) | NOX1GAAMAPTMEN1KMT2A | |
| Phenothiazine SCHEMBL28704963 | 0.80 | NOX1 (0.81) | NOX1GAAMAPTMEN1KMT2A | |
| Phenothiazine SCHEMBL9347283 | 0.78 | NOX1 (0.85) | NOX1GAAMAPTMEN1KMT2A | |
| SCHEMBL1853042 | 0.77 | NOX1 (0.83) | NOX1GAAMAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040050679-A1 | Method for producing (meth) acrylic acid | BASF AKTIENGESELLSCHAFT (DE) | 2004-03-18 | — | — | US | disclosed |
| US-20040031674-A1 | Workup of (meth)acrylic acid and (meth)acrylic esters | BASF AKIENGESELLSCHAFT (DE) | 2004-02-19 | — | — | US | disclosed |