Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 2/20 | 0.41 |
| ▸ | MAOB | P27338 | 2/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | KIF11 | P52732 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 4/20 | 0.33 |
| ▸ | DAO | P14920 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3027798 | 0.81 | HSD11B1 (0.50) | HSD11B1MEN1KMT2A | |
| SCHEMBL6895201 | 0.78 | HSD11B1 (0.46) | MAOAMAOBKDM1AOPRM1HSD11B1 | |
| SCHEMBL6680140 | 0.78 | HSD11B1 (0.46) | MAOAMAOBSLC6A3OPRM1HSD11B1 | |
| SCHEMBL6895186 | 0.78 | HSD11B1 (0.45) | OPRM1HSD11B1 | |
| SCHEMBL6897241 | 0.75 | MAOA (0.44) | MAOAMAOBKDM1ASLC6A3HSD11B1 | |
| SCHEMBL6895204 | 0.74 | HSD11B1 (0.50) | MAOAMAOBSLC6A3HSD11B1KDM4E | |
| Hydrochloric Acid SCHEMBL6897921 | 0.70 | SLC6A3 (0.46) | MAOAMAOBKDM1ASLC6A3HSD11B1 | |
| SCHEMBL3719123 | 0.68 | CYP1A2 (0.47) | MAOAMAOBKDM1AKIF11SLC6A3 | |
| SCHEMBL6893766 | 0.67 | HSD11B1 (0.42) | SLC6A3HSD11B1MEN1KMT2A | |
| SCHEMBL626219 | 0.66 | SLC6A3 (0.45) | MAOAMAOBKDM1AKIF11SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1143964-B1 | 2-ADAMANTANEMETHANAMINE COMPOUNDS FOR TREATING ABNORMALITIES IN GLUTAMATERGIC TRANSMISSION | VERNALIS RES LTD (GB) | 2004-03-24 | — | — | EP | disclosed |
| US-6531511-B1 | N-methyl aspartate receptor antagonist | VERNALIS RESEARCH LIMITED (GB) | 2003-03-11 | — | — | US | disclosed |
| EP-1143964-A1 | 2-ADAMANTANEMETHANAMINE COMPOUNDS FOR TREATING ABNORMALITIES IN GLUTAMATERGIC TRANSMISSION | VERNALIS RESEARCH LIMITED (GB) | 2001-10-17 | — | — | EP | disclosed |
| WO-2000044371-A1 | 2-ADAMANTANEMETHANAMINE COMPOUNDS FOR TREATING ABNORMALITIES IN GLUTAMATERGIC TRANSMISSION | VERNALIS RESEARCH LIMITED (GB) | 2000-08-03 | — | — | WO | disclosed |