Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNMT | Q14749 | 1/20 | 0.73 |
| ▸ | SLC29A1 | Q99808 | 2/20 | 0.69 |
| ▸ | AHCY | P23526 | 6/20 | 0.63 |
| ▸ | NADK | O95544 | 1/20 | 0.63 |
| ▸ | PNMT | P11086 | 1/20 | 0.58 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.58 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.58 |
| ▸ | DNMT3B | Q9UBC3 | 1/20 | 0.58 |
| ▸ | TRDMT1 | O14717 | 1/20 | 0.58 |
| ▸ | DPP4 | P27487 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6902241 | 0.89 | AHCY (0.68) | GNMTSLC29A1AHCYNADKPNMT | |
| SCHEMBL6907796 | 0.86 | GNMT (0.76) | GNMTSLC29A1AHCYNADKPNMT | |
| SCHEMBL6906701 | 0.84 | GNMT (0.73) | GNMTSLC29A1AHCYNADKPNMT | |
| SCHEMBL18572516 | 0.84 | GNMT (0.76) | GNMTSLC29A1AHCYNADKPNMT | |
| SCHEMBL22683279 | 0.84 | GNMT (0.76) | GNMTSLC29A1AHCYNADKPNMT | |
| SCHEMBL18572550 | 0.84 | GNMT (0.76) | GNMTSLC29A1AHCYNADKPNMT | |
| SCHEMBL6905431 | 0.81 | AHCY (0.73) | GNMTSLC29A1AHCYNADKPNMT | |
| SCHEMBL6908433 | 0.81 | AHCY (0.72) | GNMTSLC29A1AHCYNADKPNMT | |
| SCHEMBL28017953 | 0.80 | AHCY (0.78) | SLC29A1AHCYNADKPNMTDNMT1 | |
| SCHEMBL10338481 | 0.80 | GNMT (0.66) | GNMTSLC29A1AHCYNADKPNMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1482977-A1 | COMBINATION THERAPIES FOR TREATING METHYLTHIOADENOSINE PHOSPHORYLASE DEFICIENT CELLS | PFIZER INC. (US) | 2004-12-08 | — | — | EP | disclosed |
| US-20040043959-A1 | Combination therapies for treating methylthioadenosine phosphorylase deficient cells | AGOURON PHARMACEUTICALS INC. | 2004-03-04 | — | — | US | disclosed |
| WO-2003074083-A1 | COMBINATION THERAPIES FOR TREATING METHYLTHIOADENOSINE PHOSPHORYLASE DEFICIENT CELLS | PFIZER INC. (US) | 2003-09-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040043959-A1 | Combination therapies for treating methylthioadenosine phosphorylase deficient cells | APRT, MTAP, TYMP | GNMT 12/4885SLC29A1 65/4885AHCY 62/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.