Ly-293284

Ly-293284

SCHEMBL6902000

CCCN(CCC)[C@H]1Cc2c[nH]c3ccc(C(C)=O)c(c23)C1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
HTR1A P08908 1/20 1.00
HTR1D P28221 5/20 0.65
HTR1B P28222 5/20 0.65
DRD2 P14416 2/20 0.65

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Ly-293284 SCHEMBL7202815 1.00 HTR1A (1.00) HTR1AHTR1DHTR1BDRD2
Ly-293284 SCHEMBL7204055 1.00 HTR1A (1.00) HTR1AHTR1DHTR1BDRD2
SCHEMBL9412130 0.91 HTR1A (0.83) HTR1AHTR1DHTR1BDRD2
SCHEMBL8889776 0.91 HTR1A (0.83) HTR1AHTR1DHTR1BDRD2
SCHEMBL6364891 0.90 HTR1A (0.81) HTR1AHTR1DHTR1BDRD2
SCHEMBL6765275 0.90 HTR1A (0.81) HTR1AHTR1DHTR1BDRD2
SCHEMBL7208944 0.90 HTR1A (0.81) HTR1AHTR1DHTR1BDRD2
SCHEMBL8983347 0.90 HTR1A (0.81) HTR1AHTR1DHTR1BDRD2
Acetic Acid SCHEMBL7513634 0.89 HTR1A (0.80) HTR1AHTR1DHTR1BDRD2
SCHEMBL7516908 0.89 HTR1A (0.80) HTR1AHTR1DHTR1BDRD2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20140350064-A1 PHARMACEUTICAL COMPOSITION COMPRISING AN AMPK ACTIVATOR AND A SEROTONERGIC AGENT AND METHODS OF USE THEREOF ALS MOUNTAIN LLC 2014-11-27 US claimed
US-20120183600-A1 NOVEL COMPOSITION FOR TREATING METABOLIC SYNDROME AND OTHER CONDITIONS CHEN CHIEN-HUNG (US) 2012-07-19 US claimed
US-20140350064-A1 PHARMACEUTICAL COMPOSITION COMPRISING AN AMPK ACTIVATOR AND A SEROTONERGIC AGENT AND METHODS OF USE THEREOF ALS MOUNTAIN LLC 2014-11-27 US disclosed
US-20120183600-A1 NOVEL COMPOSITION FOR TREATING METABOLIC SYNDROME AND OTHER CONDITIONS CHEN CHIEN-HUNG (US) 2012-07-19 US disclosed
EP-1067965-B1 PHARMACEUTICAL COMPOSITION FOR TREATING CEREBRAL APOPLEXY AND CRANIOCEREBRAL TRAUMA BAYER HEALTHCARE AG (DE) 2004-09-29 EP disclosed
EP-0471576-B1 6-substituted-tetrahydrobenz[cd]indoles LILLY CO ELI (US) 2003-03-12 EP disclosed
EP-1000621-A2 Use of 6-heterocyclic-4-amino-1,3,4,5-tetrahydrobenz (CD) indoles for treating motion sickness and vomiting ELI LILLY AND COMPANY (US) 2000-05-17 EP disclosed
EP-0506363-B1 6-Heterocyclic-4-amino-1,3,4,5-tetrahydrobenz[cd]indoles LILLY CO ELI (US) 1999-05-19 EP disclosed
US-5665758-A SEROTONIN FUNCTION MODIFIERS ELI LILLY AND COMPANY (US) 1997-09-09 US disclosed
US-5665743-A SEROTONIN FUNCTION MODIFIERS ELI LILLY AND COMPANY (US) 1997-09-09 US disclosed
US-5643930-A SEROTONIN INHIBITORS ELI LILLY AND COMPANY (US) 1997-07-01 US disclosed
US-5641797-A USED FOR MODIFYING SEROTONIN FUNCTION IN MAMMALS ELI LILLY AND COMPANY (US) 1997-06-24 US disclosed
US-5624944-A SEROTONIN RELATED ILLNESS SUCH AS ANXIETY, DEPRESSION, ANTISECRETORY AGENTS FOR GASTRIC JUICE AND DEMENTIA ELI LILLY AND COMPANY (US) 1997-04-29 US disclosed
US-5594019-A SEROTONIN DISORDERS ELI LILLY AND COMPANY (US) 1997-01-14 US disclosed
US-5364856-A Modification of serotonin function ELI LILLY AND COMPANY (US) 1994-11-15 US disclosed
EP-0590971-A1 6-Heterocyclyl-4-amino-1,3,4,5-tetrahydrobenz CD indoles for treating motion sickness and vomiting ELI LILLY AND COMPANY (US) 1994-04-06 EP disclosed
US-5229409-A Antidepressant, tranquilizer ELI LILLY AND COMPANY (US) 1993-07-20 US disclosed
EP-0506363-A1 6-Heterocyclic-4-amino-1,3,4,5-tetrahydrobenz[cd]indoles ELI LILLY AND COMPANY (US) 1992-09-30 EP disclosed