Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 0.80 |
| ▸ | HTR1D | P28221 | 8/20 | 0.54 |
| ▸ | HTR1B | P28222 | 8/20 | 0.54 |
| ▸ | DRD2 | P14416 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7512608 | 0.90 | HTR1A (0.78) | HTR1AHTR1DHTR1BDRD2 | |
| Ly-293284 SCHEMBL7204055 | 0.89 | HTR1A (1.00) | HTR1AHTR1DHTR1BDRD2 | |
| Ly-293284 SCHEMBL6902000 | 0.89 | HTR1A (1.00) | HTR1AHTR1DHTR1BDRD2 | |
| Ly-293284 SCHEMBL7202815 | 0.89 | HTR1A (1.00) | HTR1AHTR1DHTR1BDRD2 | |
| SCHEMBL8889776 | 0.89 | HTR1A (0.83) | HTR1AHTR1DHTR1BDRD2 | |
| SCHEMBL9412130 | 0.89 | HTR1A (0.83) | HTR1AHTR1DHTR1BDRD2 | |
| SCHEMBL6364891 | 0.88 | HTR1A (0.81) | HTR1AHTR1DHTR1BDRD2 | |
| SCHEMBL6765275 | 0.88 | HTR1A (0.81) | HTR1AHTR1DHTR1BDRD2 | |
| SCHEMBL7208944 | 0.88 | HTR1A (0.81) | HTR1AHTR1DHTR1BDRD2 | |
| SCHEMBL8983347 | 0.88 | HTR1A (0.81) | HTR1AHTR1DHTR1BDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0633023-A2 | Preventing emesis and treating sexual dysfunction using tetrahydrobenz CD indole-6-carboxamides | ELI LILLY AND COMPANY (US) | 1995-01-11 | — | — | EP | claimed |
| EP-0392768-A1 | Tetrahydrobenz[C,D] indole serotonin agonists | ELI LILLY AND COMPANY (US) | 1990-10-17 | — | — | EP | claimed |
| EP-1166783-A2 | Tetrahydrobenz[CD]indole-6-carboxamides for treating sexual dysfunction | ELI LILLY AND COMPANY (US) | 2002-01-02 | — | — | EP | disclosed |
| EP-0633023-A2 | Preventing emesis and treating sexual dysfunction using tetrahydrobenz CD indole-6-carboxamides | ELI LILLY AND COMPANY (US) | 1995-01-11 | — | — | EP | disclosed |