Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6901311 | 0.82 | PTGS1 (0.31) | KDM4EALDH1A1SMN1; SMN2BRD4CREBBP | |
| Hydrochloric Acid SCHEMBL6903546 | 0.79 | GSK3B (0.36) | — | |
| Hydrochloric Acid SCHEMBL7196825 | 0.78 | PBRM1 (0.31) | ALDH1A1 | |
| Hydrochloric Acid SCHEMBL6903076 | 0.77 | — | — | |
| Hydrochloric Acid SCHEMBL6897668 | 0.75 | ADRA1A (0.34) | KDM4EALDH1A1SMN1; SMN2BRD4PKM | |
| Hydrochloric Acid SCHEMBL6917663 | 0.72 | — | — | |
| Hydrochloric Acid SCHEMBL6662549 | 0.67 | — | — | |
| Hydrochloric Acid SCHEMBL6899069 | 0.67 | ALDH1A1 (0.33) | ALDH1A1 | |
| SCHEMBL6901808 | 0.65 | GSK3B (0.34) | KDM4EALDH1A1MEN1PKMKMT2A | |
| SCHEMBL20838293 | 0.63 | BRD4 (0.33) | KDM4EALDH1A1SMN1; SMN2BRD4CREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1033371-B1 | Transition metal compound, catalyst system, process for the preparation thereof and its use for the polymerization of olefins | BASELL POLYOLEFINE GMBH (DE) | 2004-01-28 | — | — | EP | claimed |
| US-6458982-B1 | CATALYST SYSTEM COMPRISING AT LEAST ONE METALLOCENE AND AT LEAST ONE COCATALYST. ON SUPPORT. | TARGOR GMBH (DE) | 2002-10-01 | — | — | US | disclosed |