SCHEMBL6902137

SCHEMBL6902137

CC(C)N(CCOc1cccc(N)c1)C(C)C

nearest known ligand 0.55

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.55
CHRNB2 P17787 2/20 0.55
CHRNA4 P43681 2/20 0.55
CYP3A4 P08684 2/20 0.54
TP53 P04637 1/20 0.54
LTA4H P09960 1/20 0.51
MAOB P27338 1/20 0.50
KDM4E B2RXH2 1/20 0.47
ADORA2A P29274 2/20 0.46
ADORA1 P30542 2/20 0.46
APP P05067 1/20 0.46
ALDH1A1 P00352 1/20 0.46
ESR1 P03372 2/20 0.46
ESR2 Q92731 2/20 0.46
MCHR1 Q99705 2/20 0.44
KCNH2 Q12809 1/20 0.44
ACHE P22303 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7608283 0.82 CHRNB2 (0.56) TSHRCHRNB2CHRNA4LTA4HKDM4E
SCHEMBL12409068 0.82 CHRNB2 (0.56) TSHRCHRNB2CHRNA4LTA4HKDM4E
SCHEMBL1641682 0.81 CHRNB2 (0.65) TSHRCHRNB2CHRNA4CYP3A4TP53
SCHEMBL7872686 0.81 LTA4H (0.55) TSHRCHRNB2CHRNA4LTA4HKDM4E
Hydrochloric Acid SCHEMBL309555 0.80 CHRNB2 (0.63) TSHRCHRNB2CHRNA4CYP3A4TP53
Hydrochloric Acid SCHEMBL310652 0.80 CHRNB2 (0.63) TSHRCHRNB2CHRNA4CYP3A4TP53
SCHEMBL6802602 0.80 LTA4H (0.61) TSHRCHRNB2CHRNA4LTA4HMAOB
SCHEMBL7875705 0.79 TSHR (0.54) TSHRCHRNB2CHRNA4LTA4HKDM4E
SCHEMBL6443597 0.79 LTA4H (0.75) CHRNB2CHRNA4LTA4HESR1ESR2
SCHEMBL1642498 0.79 TSHR (0.63) TSHRCYP3A4TP53LTA4HMAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1100485-A4 SUBSTITUTED ANILIDE COMPOUNDS AND METHODS SMITHKLINE BEECHAM CORP (US) 2004-06-09 EP disclosed
EP-1001766-B1 COMPOUNDS FOR THE TREATMENT OF CCR5-MEDIATED DISEASES SMITHKLINE BEECHAM CORP (US) 2003-04-09 EP disclosed
US-6515027-B1 Ligands, agonists or antagonists, of the CC chemokine receptor CC-CKR5 SMITHKLINE BEECHAM CORP. 2003-02-04 US disclosed
EP-1100485-A1 SUBSTITUTED ANILIDE COMPOUNDS AND METHODS SMITHKLINE BEECHAM CORPORATION (US) 2001-05-23 EP disclosed
EP-1001766-A4 COMPOUNDS AND METHODS SMITHKLINE BEECHAM CORP (US) 2001-04-04 EP disclosed
WO-2000006146-A9 SUBSTITUTED ANILIDE COMPOUNDS AND METHODS SMITHKLINE BEECHAM CORP (US) 2000-08-03 WO disclosed
EP-1001766-A1 COMPOUNDS AND METHODS SMITHKLINE BEECHAM CORPORATION (US) 2000-05-24 EP disclosed
WO-2000006146-A1 SUBSTITUTED ANILIDE COMPOUNDS AND METHODS SMITHKLINE BEECHAM CORPORATION (US) 2000-02-10 WO disclosed
WO-1999001127-A1 COMPOUNDS AND METHODS SMITHKLINE BEECHAM CORPORATION (US) 1999-01-14 WO disclosed