Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | XBP1 | P17861 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 5/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | DDR1 | Q08345 | 4/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL690226 | 0.85 | ALDH1A1 (0.43) | ALDH1A1GAAXBP1MAPK1HTT | |
| SCHEMBL5118355 | 0.82 | CACNA1B (0.43) | ALDH1A1GAAXBP1MAPK1HTT | |
| SCHEMBL5124007 | 0.74 | SMN1; SMN2 (0.40) | HTTL3MBTL1 | |
| SCHEMBL5119240 | 0.74 | KDM4E (0.43) | ALDH1A1GAAMEN1KMT2APOLB | |
| SCHEMBL689686 | 0.71 | SSTR5 (0.42) | ALDH1A1GAAXBP1MAPK1HTT | |
| SCHEMBL10104443 | 0.69 | ALDH1A1 (0.47) | ALDH1A1GAAXBP1MAPK1HTT | |
| SCHEMBL24566256 | 0.69 | MAP4K4 (0.39) | FGFR1L3MBTL1DDR1 | |
| SCHEMBL24566865 | 0.69 | MAP4K4 (0.39) | FGFR1L3MBTL1DDR1 | |
| SCHEMBL1935976 | 0.69 | CYP2C19 (0.53) | ALDH1A1GAAMAPK1HTTMEN1 | |
| SCHEMBL10104438 | 0.68 | ALDH1A1 (0.49) | ALDH1A1GAAXBP1MAPK1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2323980-B1 | 7-(PIPERAZINE-1-YMETHYL)-1H-INDOLE-2-CARBOXYLIC ACID (PHENYL)-AMIDE DERIVATIVES AND ALLIED COMPOUNDS AS P38 MAP KINASE INHIBITORS FOR THE TREATMENT OF RESPIRATORY DISEASES | BOEHRINGER INGELHEIM INT (DE) | 2012-02-29 | — | — | EP | claimed |