Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR5 | P35346 | 2/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | XBP1 | P17861 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | NPY1R | P25929 | 1/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | HCK | P08631 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL689162 | 0.90 | SSTR5 (0.41) | SSTR5ACHEHTR4KDM4EALDH1A1 | |
| SCHEMBL690226 | 0.88 | ALDH1A1 (0.43) | SSTR5KDM4EALDH1A1MAPK1MEN1 | |
| SCHEMBL5118350 | 0.85 | POLB (0.42) | SSTR5ACHEHTR4KDM4EALDH1A1 | |
| SCHEMBL690355 | 0.83 | GAA (0.40) | SSTR5KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL5124004 | 0.82 | HCRTR1 (0.42) | SSTR5KDM4EALDH1A1MAPK1LMNA | |
| SCHEMBL1847329 | 0.81 | SSTR5 (0.43) | SSTR5KDM4EALDH1A1MAPK1MEN1 | |
| SCHEMBL691322 | 0.81 | SSTR5 (0.38) | SSTR5PARP1PARP2KDM4EMEN1 | |
| SCHEMBL5110866 | 0.78 | CYP2C19 (0.50) | KDM4EALDH1A1MAPK1MEN1KMT2A | |
| SCHEMBL5119234 | 0.78 | SCN9A (0.43) | KDM4EALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL5114802 | 0.75 | SCN9A (0.46) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2323980-B1 | 7-(PIPERAZINE-1-YMETHYL)-1H-INDOLE-2-CARBOXYLIC ACID (PHENYL)-AMIDE DERIVATIVES AND ALLIED COMPOUNDS AS P38 MAP KINASE INHIBITORS FOR THE TREATMENT OF RESPIRATORY DISEASES | BOEHRINGER INGELHEIM INT (DE) | 2012-02-29 | — | — | EP | claimed |