Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | XBP1 | P17861 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.40 |
| ▸ | DDR1 | Q08345 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 5/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL689686 | 0.88 | SSTR5 (0.42) | ALDH1A1GAAXBP1MAPK1HTT | |
| SCHEMBL690227 | 0.85 | ALDH1A1 (0.44) | ALDH1A1GAAXBP1MAPK1HTT | |
| SCHEMBL5118350 | 0.84 | POLB (0.42) | ALDH1A1GAAXBP1MAPK1HTT | |
| SCHEMBL689162 | 0.80 | SSTR5 (0.41) | ALDH1A1GAAXBP1MAPK1HTT | |
| SCHEMBL690355 | 0.78 | GAA (0.40) | ALDH1A1GAAPOLBMEN1KMT2A | |
| SCHEMBL5124004 | 0.77 | HCRTR1 (0.42) | ALDH1A1MAPK1HTTSSTR5KDM4E | |
| SCHEMBL5119234 | 0.77 | SCN9A (0.43) | ALDH1A1POLBMEN1KMT2AL3MBTL1 | |
| SCHEMBL691322 | 0.75 | SSTR5 (0.38) | MEN1KMT2ASSTR5KDM4E | |
| SCHEMBL5110866 | 0.72 | CYP2C19 (0.50) | ALDH1A1MAPK1HTTMEN1KMT2A | |
| SCHEMBL689665 | 0.71 | MAPT (0.41) | ALDH1A1HTTPOLBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2323980-B1 | 7-(PIPERAZINE-1-YMETHYL)-1H-INDOLE-2-CARBOXYLIC ACID (PHENYL)-AMIDE DERIVATIVES AND ALLIED COMPOUNDS AS P38 MAP KINASE INHIBITORS FOR THE TREATMENT OF RESPIRATORY DISEASES | BOEHRINGER INGELHEIM INT (DE) | 2012-02-29 | — | — | EP | claimed |