Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6904462 | 0.92 | — | — | |
| Hydrochloric Acid SCHEMBL6904276 | 0.92 | — | — | |
| Hydrochloric Acid SCHEMBL6902101 | 0.91 | CHRM2 (0.33) | KDM4EDDAH1ALDH1A1CYP1A2CYP2C19 | |
| Hydrochloric Acid SCHEMBL6902512 | 0.91 | ALDH1A1 (0.33) | ALDH1A1CYP1A2CYP2C19 | |
| Hydrochloric Acid SCHEMBL6899174 | 0.90 | — | — | |
| Hydrochloric Acid SCHEMBL6903254 | 0.89 | — | — | |
| Hydrochloric Acid SCHEMBL6903364 | 0.89 | CHRM2 (0.34) | ALDH1A1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL6903328 | 0.89 | CHRM2 (0.30) | — | |
| Hydrochloric Acid SCHEMBL6900458 | 0.87 | ALOX5 (0.34) | ALDH1A1 | |
| Hydrochloric Acid SCHEMBL6903376 | 0.87 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1033371-B1 | Transition metal compound, catalyst system, process for the preparation thereof and its use for the polymerization of olefins | BASELL POLYOLEFINE GMBH (DE) | 2004-01-28 | — | — | EP | claimed |
| US-6458982-B1 | CATALYST SYSTEM COMPRISING AT LEAST ONE METALLOCENE AND AT LEAST ONE COCATALYST. ON SUPPORT. | TARGOR GMBH (DE) | 2002-10-01 | — | — | US | disclosed |