Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.60 |
| ▸ | TSHR | P16473 | 3/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.60 |
| ▸ | ATM | Q13315 | 1/20 | 0.60 |
| ▸ | CA2 | P00918 | 3/20 | 0.53 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 4/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.47 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.47 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.47 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | MMP8 | P22894 | 1/20 | 0.41 |
| ▸ | MMP14 | P50281 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14625765 | 0.93 | CYP3A4 (0.68) | ALDH1A1CYP3A4TSHRTDP1ATM | |
| SCHEMBL146937 | 0.93 | CYP3A4 (0.68) | ALDH1A1CYP3A4TSHRTDP1ATM | |
| SCHEMBL10930013 | 0.91 | CYP3A4 (0.66) | ALDH1A1CYP3A4TSHRTDP1ATM | |
| Ammonia Solution, Strong SCHEMBL1878882 | 0.91 | CYP3A4 (0.66) | ALDH1A1CYP3A4TSHRTDP1ATM | |
| SCHEMBL28146062 | 0.91 | CYP3A4 (0.66) | ALDH1A1CYP3A4TSHRTDP1ATM | |
| Acetic Acid SCHEMBL28184357 | 0.89 | CYP3A4 (0.64) | ALDH1A1CYP3A4TSHRTDP1ATM | |
| SCHEMBL28748130 | 0.87 | CYP3A4 (0.61) | ALDH1A1CYP3A4TSHRTDP1ATM | |
| Phosphoric Acid SCHEMBL28839428 | 0.86 | CYP3A4 (0.60) | ALDH1A1CYP3A4TSHRTDP1ATM | |
| Acetic Acid Propyl Ester SCHEMBL8079133 | 0.86 | CYP3A4 (0.60) | ALDH1A1CYP3A4TSHRTDP1ATM | |
| SCHEMBL8200825 | 0.86 | LMNA (0.55) | ALDH1A1CYP3A4TSHRTDP1ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040097544-A1 | Use of an inhibitor of the Na+/H+ exchanger for the production of a medicament for the treatment or prophylaxis of disturbances of the central nervous system | HOECHST MARION ROUSSEL DEUTSCHLAND GMBH | 2004-05-20 | — | — | US | claimed |
| US-6420430-B1 | USE OF BENZOYLGUANIDINE DERIVATIVES TO PREVENT AGING DISORDERS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2002-07-16 | — | — | US | claimed |
| EP-0738712-B1 | Anti-arrhythmic and cardioprotective substituted indenoylguanidines | HOECHST AG (DE) | 1999-08-18 | — | — | EP | claimed |
| EP-0738712-A1 | Anti-arrhythmic and cardioprotective substituted indenoylguanidines | HOECHST AKTIENGESELLSCHAFT (DE) | 1996-10-23 | — | — | EP | claimed |
| CN-1211370-C | Imidazole derivatives with biphenylsulfonyl substituents, process for their preparation and their use as pharmaceuticals or diagnostic agents | AVENTIS PHARMA GMBH (DE) | 2005-07-20 | — | — | CN | disclosed |
| US-6680404-B1 | CONDENSING ACYCLIC ESTERS WITH OXY ALDEHYDES IN THE PRESENCE OF GROUP I COMPOUNDS, THEN DISTILLING THE ALCOHOLS AND COLLECTING OXY UNSATURATED CARBOCYCLIC ESTERS FORMED USED AS SUNSCREEN AGENTS | SYMRISE GMBH & CO. KG (DE) | 2004-01-20 | — | — | US | disclosed |
| US-6369110-B1 | PROPHYLACTIC AGENT FOR DISEASES CAUSED BY THE ACCELERATION OF THE SODIUM/PROTON EXCHANGE TRANSPORT SYSTEM | SUMITOMO PHARMACEUTICALS COMPANY (JP) | 2002-04-09 | — | — | US | disclosed |
| CN-1309645-A | Imidazole derivatives with biphenylsulfonyl substituents, process for their preparation and their use as pharmaceuticals or diagnostic agents | AVENTIS PHARMA GMBH (DE) | 2001-08-22 | — | — | CN | disclosed |
| EP-1083166-A1 | NOVEL SUBSTITUTED GUANIDINE DERIVATIVES AND PROCESS FOR PRODUCING THE SAME | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2001-03-14 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040097544-A1 | Use of an inhibitor of the Na+/H+ exchanger for the production of a medicament for the treatment or prophylaxis of disturbances of the central nervous system | SLC9A2, SLC6A2, SLC9A1 | ALDH1A1 2739/4885CYP3A4 3397/4885TSHR 1329/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.