Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIN1 | Q13526 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | MMP8 | P22894 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5474434 | 0.90 | PIN1 (0.53) | PIN1ALDH1A1RECQLMMP8POLB | |
| SCHEMBL2822944 | 0.87 | PIN1 (0.50) | PIN1ALDH1A1RECQLMMP8POLB | |
| SCHEMBL15945879 | 0.84 | PIN1 (0.47) | PIN1ALDH1A1RECQLMMP8POLB | |
| SCHEMBL27546110 | 0.83 | PIN1 (0.46) | PIN1ALDH1A1RECQLMMP8POLB | |
| SCHEMBL2761314 | 0.81 | PIN1 (0.51) | PIN1ALDH1A1RECQLMMP8POLB | |
| SCHEMBL15944491 | 0.81 | MMP8 (0.47) | PIN1ALDH1A1RECQLMMP8POLB | |
| Adipic Acid SCHEMBL27846408 | 0.81 | PIN1 (0.45) | PIN1ALDH1A1RECQLMMP8POLB | |
| SCHEMBL10772966 | 0.81 | PIN1 (0.36) | PIN1ALDH1A1RECQLMMP8POLB | |
| SCHEMBL7374269 | 0.80 | PIN1 (0.50) | PIN1ALDH1A1RECQLMMP8POLB | |
| SCHEMBL27486575 | 0.80 | PIN1 (0.50) | PIN1ALDH1A1RECQLMMP8POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0768895-B1 | CAMPTOTHECIN DRUG COMBINATIONS AND MEDICAMENTS WITH REDUCED SIDE EFFECTS | ARCH DEV CORP (US) | 2004-09-22 | — | — | EP | disclosed |
| US-20020016293-A1 | Flavopiridol drug combinations and methods with reduced side effects | NIH - DEITR | 2002-02-07 | — | — | US | disclosed |
| WO-2001080896-A2 | FLAVOPIRIDOL DRUG COMBINATIONS AND METHODS WITH REDUCED SIDE EFFECTS | ARCH DEVELOPMENT CORPORATION (US) | 2001-11-01 | — | — | WO | disclosed |
| US-5786344-A | ADMINISTERING WITH AGENT WHICH INCREASES ACTIVITY OF GLUCURONOSYLTRANSFERASE OR DECREASES ACTIVITY OF BILIARY TRANSPORT PROTEIN | ARCH DEVELOPMENT CORPORATION (US) | 1998-07-28 | — | — | US | disclosed |
| EP-0768895-A1 | CAMPTOTHECIN DRUG COMBINATIONS AND MEDICAMENTS WITH REDUCED SIDE EFFECTS | ARCH DEVELOPMENT CORPORATION (US) | 1997-04-23 | — | — | EP | disclosed |
| WO-1996001127-A1 | CAMPTOTHECIN DRUG COMBINATIONS AND MEDICAMENTS WITH REDUCED SIDE EFFECTS | ARCH DEVELOPMENT CORPORATION (US) | 1996-01-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020016293-A1 | Flavopiridol drug combinations and methods with reduced side effects | UGT1A1, UGT1A3, CYP7A1 | PIN1 843/4885ALDH1A1 325/4885RECQL 808/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.