Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 0.57 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.57 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.57 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | DRD4 | P21917 | 2/20 | 0.47 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6221439 | 0.84 | HTR2A (0.49) | ADRB2HTR2CHTR2BHTR2APOLB | |
| SCHEMBL11419578 | 0.82 | HTR1A (0.58) | HTR1AADRA1DADRA1AADRA1BL3MBTL1 | |
| SCHEMBL11566953 | 0.78 | MRGPRX4 (0.46) | HTR1AADRA1DADRA1AADRA1BENPP2 | |
| SCHEMBL29742293 | 0.74 | L3MBTL1 (0.70) | HTR1AADRA1DADRA1AADRA1BL3MBTL1 | |
| SCHEMBL29742239 | 0.74 | L3MBTL1 (0.77) | HTR1AADRA1DADRA1AADRA1BL3MBTL1 | |
| SCHEMBL5241228 | 0.74 | TAAR1 (0.68) | CYP3A4HTR2BHTR3EHTR3BHTR3A | |
| SCHEMBL1541828 | 0.74 | SMN1; SMN2 (0.47) | HTR1AADRA1DADRA1AADRA1BL3MBTL1 | |
| SCHEMBL3096336 | 0.73 | TAAR1 (0.57) | CYP3A4HTR2CHTR2BHTR3EHTR3B | |
| SCHEMBL791938 | 0.73 | HTR1A (0.60) | HTR1AADRA1DADRA1AADRA1BL3MBTL1 | |
| SCHEMBL7438250 | 0.73 | ABCB1 (0.56) | HTR1AADRA1DADRA1AADRA1BMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1425002-A1 | ARYLOXYPROPYLAMINES AS CHEMOSENSITIZING AGENTS IN THE TREATMENT OF CANCER | Ramot at Tel Aviv University Ltd. (IL) | 2004-06-09 | — | — | EP | disclosed |
| WO-2003022258-A1 | ARYLOXYPROPYLAMINES AS CHEMOSENSITIZING AGENT IN THE TREATMENT OF CANCER | RAMOT AT TEL AVIV UNIVERSITY LTD. (IL) | 2003-03-20 | — | — | WO | disclosed |