Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 3/20 | 0.30 |
| ▸ | MEN1 | O00255 | 2/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.30 |
| ▸ | POLB | P06746 | 2/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14718270 | 0.94 | RAF1 (0.32) | LMNAMAPT | |
| SCHEMBL6902447 | 0.85 | ALPL (0.39) | — | |
| SCHEMBL14718043 | 0.84 | GRIN2B (0.32) | MEN1KMT2APOLB | |
| SCHEMBL1658570 | 0.83 | MMP2 (0.31) | — | |
| SCHEMBL14718030 | 0.82 | LMNA (0.41) | LMNAMEN1KMT2APOLBTP53 | |
| SCHEMBL1660140 | 0.81 | SCN9A (0.35) | LMNA | |
| SCHEMBL14727922 | 0.80 | NTRK1 (0.33) | KMT2A | |
| SCHEMBL14727921 | 0.80 | ALPL (0.42) | — | |
| SCHEMBL14727927 | 0.79 | CXCR1 (0.34) | LMNA | |
| SCHEMBL14718186 | 0.79 | GRIN1 (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011046774-A1 | DIARYL ETHER DERIVATIVES AS NOTCH SPARING GAMMA SECRETASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2011-04-21 | — | — | WO | disclosed |