Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTAFR known ✓ | P25105 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | EDNRB | P24530 | 1/20 | 0.33 |
| ▸ | EDNRA | P25101 | 1/20 | 0.33 |
| ▸ | F2 | P00734 | 1/20 | 0.33 |
| ▸ | F12 | P00748 | 1/20 | 0.33 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.32 |
| ▸ | NMBR | P28336 | 1/20 | 0.32 |
| ▸ | GRPR | P30550 | 1/20 | 0.32 |
| ▸ | BRS3 | P32247 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6902927 | 0.92 | BRS3 (0.35) | NPC1RAB9ACYP1A2CYP2D6CYP19A1 | |
| Hydrochloric Acid SCHEMBL6901151 | 0.90 | CYP1A2 (0.38) | CYP1A2CYP2D6CYP19A1CYP2C9CYP2C19 | |
| Hydrochloric Acid SCHEMBL6904848 | 0.88 | CYP1A2 (0.36) | NPC1MAPTRAB9ASMN1; SMN2CYP1A2 | |
| Hydrochloric Acid SCHEMBL6903579 | 0.88 | SYK (0.40) | NPC1MAPTRAB9ASMN1; SMN2CYP1A2 | |
| Hydrochloric Acid SCHEMBL6903334 | 0.88 | TGFBR1 (0.38) | NPC1MAPTRAB9ASMN1; SMN2CYP1A2 | |
| Hydrochloric Acid SCHEMBL6902696 | 0.86 | PDK2 (0.30) | — | |
| Hydrochloric Acid SCHEMBL6904046 | 0.86 | ALDH1A1 (0.33) | NPC1RAB9ASMN1; SMN2CYP1A2CYP2D6 | |
| Hydrochloric Acid SCHEMBL6903073 | 0.85 | CYP3A4 (0.33) | NPC1MAPTRAB9ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL6903521 | 0.85 | TGFBR1 (0.39) | MAPTTDP1 | |
| Hydrochloric Acid SCHEMBL6904878 | 0.85 | TRPV1 (0.39) | NPC1MAPTRAB9AHPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1033371-B1 | Transition metal compound, catalyst system, process for the preparation thereof and its use for the polymerization of olefins | BASELL POLYOLEFINE GMBH (DE) | 2004-01-28 | — | — | EP | claimed |
| US-6458982-B1 | CATALYST SYSTEM COMPRISING AT LEAST ONE METALLOCENE AND AT LEAST ONE COCATALYST. ON SUPPORT. | TARGOR GMBH (DE) | 2002-10-01 | — | — | US | disclosed |