SCHEMBL6904512

SCHEMBL6904512

CC(=O)OC(CC(C)C)C(C)=O

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.46
CHRM2 P08172 1/20 0.40
CHRM4 P08173 1/20 0.40
CHRM1 P11229 1/20 0.40
TBXA2R P21731 1/20 0.40
GALR3 O60755 1/20 0.39
MAPT P10636 1/20 0.39
BLM P54132 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
LAP3 P28838 2/20 0.35
FOLH1 Q04609 2/20 0.35
ALDH1A1 P00352 2/20 0.35
TDP1 Q9NUW8 1/20 0.35
RNPEP Q9H4A4 1/20 0.34
SLC7A5 Q01650 1/20 0.34
CACNA2D1 P54289 2/20 0.34
CACNB3 P54284 1/20 0.34
CACNA1C Q13936 1/20 0.34
PGR P06401 1/20 0.34
ADRA1A P35348 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16286566 0.84 FOLH1 (0.49) TSHRCHRM2CHRM4CHRM1TBXA2R
SCHEMBL2482032 0.84 FOLH1 (0.49) TSHRCHRM2CHRM4CHRM1TBXA2R
SCHEMBL5349785 0.82 TSHR (0.42) TSHRCHRM2CHRM4CHRM1TBXA2R
SCHEMBL5349776 0.82 TSHR (0.42) TSHRCHRM2CHRM4CHRM1TBXA2R
SCHEMBL15945449 0.80 TSHR (0.41) TSHRCHRM2CHRM4CHRM1TBXA2R
SCHEMBL5744873 0.79 TSHR (0.44) TSHRCHRM2CHRM4CHRM1TBXA2R
SCHEMBL14560234 0.78 LAP3 (0.36) TSHRLAP3FOLH1ALDH1A1TDP1
SCHEMBL1781745 0.78 LAP3 (0.36) TSHRLAP3FOLH1ALDH1A1TDP1
SCHEMBL766233 0.77 TSHR (0.56) TSHRCHRM2CHRM4CHRM1TBXA2R
SCHEMBL14087827 0.77 TSHR (0.56) TSHRCHRM2CHRM4CHRM1TBXA2R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0952140-B1 2-Hydroxy-5-methyl-hexan-3-one and 3-hydroxy-5-methyl-hexan-2-one GIVAUDAN SA (CH) 2004-04-28 EP claimed
US-6426108-B1 CHLORINATION KETONE USING SULFURYL CHLORIDE; ESTERIFICATION; HYDROLYSIS GIVAUDAN SA (CH) 2002-07-30 US claimed
EP-0952140-A1 Hydroxy-methyl-hexanones Givaudan Roure (International) S.A. (CH) 1999-10-27 EP claimed
EP-0952140-B1 2-Hydroxy-5-methyl-hexan-3-one and 3-hydroxy-5-methyl-hexan-2-one GIVAUDAN SA (CH) 2004-04-28 EP disclosed
US-6426108-B1 CHLORINATION KETONE USING SULFURYL CHLORIDE; ESTERIFICATION; HYDROLYSIS GIVAUDAN SA (CH) 2002-07-30 US disclosed
US-6123974-A 2-HYDROXY-5-METHYL-HEXAN-3-ONE AND MIXTURES WITH 3-HYDROXY-5-METHYL-HEXAN-2-ONE; USE AS FLAVORING AND MASKING AGENTS SUCH AS FOR SOYBEAN-BASED FOOD AND BEVERAGES GIVAUDAN ROURE (INTERNATIONAL) SA (CH) 2000-09-26 US disclosed
EP-0952140-A1 Hydroxy-methyl-hexanones Givaudan Roure (International) S.A. (CH) 1999-10-27 EP disclosed