Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | F2RL1 | P55085 | 1/20 | 0.49 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.47 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | LDHA | P00338 | 1/20 | 0.46 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.46 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2238188 | 0.93 | HTT (0.59) | ALDH1A1SMN1; SMN2HTTF2RL1CALM1 | |
| SCHEMBL2942342 | 0.93 | HTT (0.59) | ALDH1A1SMN1; SMN2HTTF2RL1CALM1 | |
| SCHEMBL12888466 | 0.82 | CALM1 (0.59) | ALDH1A1SMN1; SMN2HTTF2RL1CALM1 | |
| SCHEMBL10697363 | 0.82 | CALM1 (0.59) | ALDH1A1SMN1; SMN2HTTF2RL1CALM1 | |
| SCHEMBL7277594 | 0.80 | HTT (0.56) | ALDH1A1SMN1; SMN2HTTF2RL1CALM1 | |
| SCHEMBL24799947 | 0.79 | F2RL1 (0.66) | ALDH1A1SMN1; SMN2HTTF2RL1KMT2A | |
| SCHEMBL20610764 | 0.79 | F2RL1 (0.66) | ALDH1A1SMN1; SMN2HTTF2RL1KMT2A | |
| SCHEMBL7604631 | 0.79 | HTT (0.56) | ALDH1A1SMN1; SMN2HTTF2RL1CALM1 | |
| SCHEMBL11079473 | 0.78 | CYP1A2 (0.58) | SMN1; SMN2HTTKDM4EMAPT | |
| SCHEMBL8338309 | 0.78 | CYP1A2 (0.58) | SMN1; SMN2HTTKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6821783-B1 | FOR PI-ORBITAL CONTAINING SUBSTRATE FOR SUBSEQUENT SYNTHESIS BY COMBINATORIAL CHEMISTRY/MULTIPLE PARALLEL SYNTHESIS (MPS); SOLID PHASE SYNTHESIS | ASTRAZENECA AB (SE) | 2004-11-23 | — | — | US | disclosed |
| EP-1100759-B1 | TRANSITION METAL COMPLEXES AS LINKERS | ASTRAZENECA AB (SE) | 2003-03-26 | — | — | EP | disclosed |
| EP-1100759-A1 | TRANSITION METAL COMPLEXES AS LINKERS | AstraZeneca AB (SE) | 2001-05-23 | — | — | EP | disclosed |
| WO-2000007966-A1 | TRANSITION METAL COMPLEXES AS LINKERS | ASTRAZENECA AB (SE) | 2000-02-17 | — | — | WO | disclosed |