Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 8/20 | 0.36 |
| ▸ | CTSD | P07339 | 2/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 8/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 7/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.36 |
| ▸ | TSHR | P16473 | 7/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 7/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.36 |
| ▸ | USP2 | O75604 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1768100 | 0.71 | BACE1 (0.41) | LCKKDRJAK3MAPK14BACE1 | |
| SCHEMBL1767842 | 0.68 | BACE1 (0.54) | LCKKDRJAK3MAPK14BACE1 | |
| SCHEMBL1767821 | 0.68 | BACE1 (0.40) | LCKKDRJAK3MAPK14BACE1 | |
| SCHEMBL14273 | 0.62 | BACE1 (0.41) | LCKKDRJAK3MAPK14BACE1 | |
| SCHEMBL1767863 | 0.61 | BACE1 (0.55) | LCKKDRJAK3MAPK14BACE1 | |
| SCHEMBL5491478 | 0.59 | LCK (0.69) | LCKKDRJAK3MAPK14BACE1 | |
| SCHEMBL1767758 | 0.57 | BACE1 (0.57) | LCKKDRJAK3MAPK14BACE1 | |
| SCHEMBL24079158 | 0.57 | TGFBR1 (0.40) | LCKKDRJAK3MAPK14BACE1 | |
| SCHEMBL5157768 | 0.57 | CTSD (0.60) | LCKKDRJAK3MAPK14BACE1 | |
| SCHEMBL28177941 | 0.57 | BACE1 (0.56) | LCKKDRJAK3MAPK14BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011063272-A1 | AMINO HETEROARYL COMPOUNDS AS BETA-SECRETASE MODULATORS AND METHODS OF USE | AMGEN INC. (US) | 2011-05-26 | — | — | WO | disclosed |