Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 7/20 | 0.67 |
| ▸ | SHBG | P04278 | 2/20 | 0.59 |
| ▸ | SERPINA6 | P08185 | 2/20 | 0.59 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | THRB | P10828 | 1/20 | 0.59 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | PGR | P06401 | 4/20 | 0.44 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.44 |
| ▸ | PDK1 | Q15118 | 2/20 | 0.42 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.42 |
| ▸ | PDK3 | Q15120 | 2/20 | 0.42 |
| ▸ | PDK4 | Q16654 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4259619 | 1.00 | AR (0.67) | ARSHBGSERPINA6SLC22A1ALDH1A1 | |
| SCHEMBL24711580 | 0.91 | AR (0.66) | ARSHBGSERPINA6SLC22A1ALDH1A1 | |
| SCHEMBL6836638 | 0.89 | AR (0.71) | ARSHBGSERPINA6SLC22A1ALDH1A1 | |
| SCHEMBL7706417 | 0.89 | AR (0.71) | ARSHBGSERPINA6SLC22A1ALDH1A1 | |
| SCHEMBL4265902 | 0.87 | AR (0.61) | ARSHBGSERPINA6SLC22A1ALDH1A1 | |
| SCHEMBL6241583 | 0.86 | AR (0.74) | ARSHBGSERPINA6SLC22A1ALDH1A1 | |
| SCHEMBL24102607 | 0.86 | AR (0.74) | ARSHBGSERPINA6SLC22A1ALDH1A1 | |
| SCHEMBL6841921 | 0.86 | AR (0.74) | ARSHBGSERPINA6SLC22A1ALDH1A1 | |
| SCHEMBL24102603 | 0.86 | AR (0.74) | ARSHBGSERPINA6SLC22A1ALDH1A1 | |
| SCHEMBL6836662 | 0.86 | AR (0.74) | ARSHBGSERPINA6SLC22A1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0943328-B1 | Combination therapy for prophylaxis and/or treatment of benign prostatic hyperplasia | ENDORECH INC (CA) | 2004-06-16 | — | — | EP | disclosed |
| EP-0595796-B1 | METHOD OF TREATMENT OF ANDROGEN-RELATED DISEASES | ENDORECH INC (CA) | 2003-01-15 | — | — | EP | disclosed |
| US-6423698-B1 | ADMINISTERING INHIBITOR OF 17-BETA-HYDROXYSTEROID DEHYDROGENASE AND AT LEAST ONE OF AN INHIBITOR OF AROMATASE AND INHIBITOR OF 5-ALPHA-REDUCTASE | ENDORECHERCHE, INC. (CA) | 2002-07-23 | — | — | US | disclosed |
| EP-0943328-A2 | Combination therapy for prophylaxis and/or treatment of benign prostatic hyperplasia | ENDORECHERCHE INC. (CA) | 1999-09-22 | — | — | EP | disclosed |
| EP-0480950-B1 | COMBINATION THERAPY FOR PROPHYLAXIS AND/OR TREATMENT OF BENIGN PROSTATIC HYPERPLASIA | ENDORECHERCHE INC (CA) | 1999-03-24 | — | — | EP | disclosed |
| US-5840735-A | ESTROGEN | ENDORECHERCHE INC. (CA) | 1998-11-24 | — | — | US | disclosed |
| US-5817649-A | Combination therapy for the prophylaxis and/or treatment of benign prostatic hyperplasia | ENDORECHERCHE, INC. (CA) | 1998-10-06 | — | — | US | disclosed |
| EP-0857487-A2 | Combinations for prophylaxsis and/or treatment of benign prostatic hyperplasia containing a 17 beta-hydroxy steroid dehydrogenase (17bHSD) inhibitor and at least one further active ingredient | ENDORECHERCHE INC. (CA) | 1998-08-12 | — | — | EP | disclosed |
| US-5686465-A | PROVIDE ANTIESTROGENIC EFFECTS; USEFUL IN TREATMENT OF BREAST CANCER | ENDORECHERCHE INC. (CA) | 1997-11-11 | — | — | US | disclosed |
| US-5686437-A | Estrogen nucleus derivatives for use in the inhibition of sex steroid activity | ENDORECHERCHE INC. (CA) | 1997-11-11 | — | — | US | disclosed |
| US-5595985-A | Combination therapy for prophylaxis and/or treatment of benign prostatic hyperplasia | ENDORECHERCHE INC. (CA) | 1997-01-21 | — | — | US | disclosed |
| US-5593981-A | Method and treatment of androgen-related diseases | ENDORECHERCHE INC. (CA) | 1997-01-14 | — | — | US | disclosed |
| US-5395842-A | Inhibitors of sex steroids | ENDORECHERCHE INC. (CA) | 1995-03-07 | — | — | US | disclosed |
| US-5372996-A | Method of treatment of androgen-related diseases | ENDORECHERCHE, INC. (CA) | 1994-12-13 | — | — | US | disclosed |
| EP-0615448-A1 | SEX STEROID ACTIVITY INHIBITORS | ENDORECHERCHE INC. (CA) | 1994-09-21 | — | — | EP | disclosed |
| WO-1993010741-A2 | SEX STEROID ACTIVITY INHIBITORS | ENDORECHERCHE INC. (CA) | 1993-06-10 | — | — | WO | disclosed |
| US-5204337-A | Estrogen nucleus derivatives for use in inhibition of sex steroid activity | ENDORECHERCHE INC. (CA) | 1993-04-20 | — | — | US | disclosed |
| WO-1991000731-A1 | COMBINATION THERAPY FOR PROPHYLAXIS AND/OR TREATMENT OF BENIGN PROSTATIC HYPERPLASIA | ENDORECHERCHE INC. (CA) | 1991-01-24 | — | — | WO | disclosed |
| WO-1991000733-A1 | METHOD OF TREATMENT OF ANDROGEN-RELATED DISEASES | ENDORECHERCHE INC. (CA) | 1991-01-24 | — | — | WO | disclosed |
| EP-0367576-A2 | Estrogen nucleus derivatives for use in the inhibition of sex steroid activity | ENDORECHERCHE INC. (CA) | 1990-05-09 | — | — | EP | disclosed |