Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 8/20 | 0.61 |
| ▸ | SERPINA6 | P08185 | 2/20 | 0.53 |
| ▸ | SHBG | P04278 | 2/20 | 0.53 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | THRB | P10828 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | PGR | P06401 | 3/20 | 0.43 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.41 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.41 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.41 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6904362 | 0.91 | LMNA (0.53) | ARSERPINA6SHBGSLC22A1ALDH1A1 | |
| SCHEMBL7028398 | 0.91 | LMNA (0.53) | ARSERPINA6SHBGSLC22A1ALDH1A1 | |
| SCHEMBL8892914 | 0.91 | LMNA (0.53) | ARSERPINA6SHBGSLC22A1ALDH1A1 | |
| SCHEMBL6841812 | 0.88 | AR (0.66) | ARSERPINA6SHBGSLC22A1ALDH1A1 | |
| SCHEMBL4259619 | 0.87 | AR (0.67) | ARSERPINA6SHBGSLC22A1ALDH1A1 | |
| SCHEMBL6905409 | 0.87 | AR (0.67) | ARSERPINA6SHBGSLC22A1ALDH1A1 | |
| SCHEMBL7030182 | 0.86 | CYP19A1 (0.49) | ARSERPINA6MAPTLMNAPGR | |
| SCHEMBL9626851 | 0.86 | CYP19A1 (0.49) | ARSERPINA6MAPTLMNAPGR | |
| SCHEMBL24711580 | 0.86 | AR (0.66) | ARSERPINA6SHBGSLC22A1ALDH1A1 | |
| SCHEMBL7706417 | 0.84 | AR (0.71) | ARSERPINA6SHBGSLC22A1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090062236-A1 | Programmable genotoxic agents and uses therefor | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2009-03-05 | — | — | US | disclosed |
| US-7169611-B2 | Programmable genotoxic agents and uses therefor | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2007-01-30 | — | — | US | disclosed |
| US-20030220311-A1 | Programmable genotoxic agents and uses therefor | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 2003-11-27 | — | — | US | disclosed |
| US-6500669-B1 | FOR SELECTIVELY KILLING A SUBPOPULATION OF CELLS IN A HETEROGENOUS CELL POPULATION; ALKYLATING AGENTS OR HEAVY METAL COORDINATION COMPOUNDS LINKED TO A COMPOUND THAT BINDS TO STEROID RECEPTOR | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 2002-12-31 | — | — | US | disclosed |