Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.69 |
| ▸ | EGLN1 | Q9GZT9 | 4/20 | 0.69 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.69 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.69 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | SLC13A3 | Q8WWT9 | 1/20 | 0.59 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.59 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.50 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | KDM5C | P41229 | 3/20 | 0.45 |
| ▸ | PHF8 | Q9UPP1 | 3/20 | 0.45 |
| ▸ | KDM2A | Q9Y2K7 | 3/20 | 0.45 |
| ▸ | KDM6B | O15054 | 2/20 | 0.45 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.45 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.45 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Succinic Acid SCHEMBL27518008 | 0.92 | LMNA (0.69) | LMNAEGLN1ALKBH5SUCNR1MAPK1 | |
| Succinic Acid SCHEMBL10385827 | 0.89 | LMNA (0.64) | LMNAEGLN1ALKBH5SUCNR1MAPK1 | |
| Succinic Acid SCHEMBL29420129 | 0.88 | LMNA (0.90) | LMNAEGLN1ALKBH5SUCNR1MAPK1 | |
| Succinic Acid SCHEMBL3129741 | 0.86 | LMNA (0.61) | LMNAEGLN1ALKBH5SUCNR1MAPK1 | |
| Succinic Acid SCHEMBL11154339 | 0.86 | LMNA (0.60) | LMNAEGLN1ALKBH5SUCNR1MAPK1 | |
| Succinic Acid SCHEMBL104934 | 0.86 | — | — | |
| Succinic Acid SCHEMBL151456 | 0.86 | LMNA (0.60) | LMNAEGLN1ALKBH5SUCNR1MAPK1 | |
| Succinic Acid SCHEMBL18839954 | 0.86 | LMNA (0.60) | LMNAEGLN1ALKBH5SUCNR1MAPK1 | |
| Succinic Acid SCHEMBL155053 | 0.86 | LMNA (0.60) | LMNAEGLN1ALKBH5SUCNR1MAPK1 | |
| Succinic Acid SCHEMBL619046 | 0.86 | LMNA (0.60) | LMNAEGLN1ALKBH5SUCNR1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118308385-A | Method for producing succinic acid by over-expressing corynebacterium glutamicum acid tolerance gene mshA | 天津大学 | 2024-07-09 | — | — | CN | disclosed |
| US-6673376-B1 | DISSOLVING IN CONTAINER SOLID ACID AND SALT; MIXING ACID-REACTING COMPONENT WITH THE ALKALINE REACTING BICARBONATE; STORAGE | FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH (DE) | 2004-01-06 | — | — | US | disclosed |
| EP-0247620-B1 | PRODUCTION OF CYCLOPENTENONES | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1993-05-05 | — | — | EP | disclosed |
| US-4970345-A | REARRANGEMENT, HYDROGENATION, DEHYDRATION | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1990-11-13 | — | — | US | disclosed |
| US-4957867-A | Production of cyclopentenones by enzyme resolution | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1990-09-18 | — | — | US | disclosed |
| EP-0247620-A2 | Production of cyclopentenones | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1987-12-02 | — | — | EP | disclosed |
| US-4496767-A | REARRANGEMENT, ESTERIFICATION AND REDUCTION OF A FURAN-CARBINOL | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1985-01-29 | — | — | US | disclosed |