Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.60 |
| ▸ | IDO1 | P14902 | 1/20 | 0.60 |
| ▸ | HTR2A | P28223 | 1/20 | 0.50 |
| ▸ | BCL2 | P10415 | 1/20 | 0.48 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.48 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL972711 | 0.81 | CALM1 (0.69) | HTR2ABCL2BCL2L1CALM1L3MBTL1 | |
| SCHEMBL3130671 | 0.80 | SLC6A2 (0.67) | HTR2ABCL2BCL2L1CALM1SLC6A2 | |
| SCHEMBL28453476 | 0.78 | HDAC8 (0.68) | L3MBTL1ALOX5MEN1KMT2AHDAC8 | |
| SCHEMBL208455 | 0.76 | — | — | |
| SCHEMBL28863273 | 0.75 | IDO1 (0.85) | THRBIDO1CALM1MEN1KMT2A | |
| SCHEMBL1773099 | 0.75 | HTR2A (0.56) | HTR2ABCL2BCL2L1CALM1L3MBTL1 | |
| SCHEMBL1506234 | 0.74 | L3MBTL1 (0.56) | THRBIDO1HTR2ABCL2BCL2L1 | |
| Bromide SCHEMBL23360794 | 0.74 | IDO1 (0.94) | THRBIDO1MEN1KMT2ACYP3A4 | |
| Hydrochloric Acid SCHEMBL359448 | 0.74 | IDO1 (0.94) | THRBIDO1MEN1KMT2ACYP3A4 | |
| Ammonia Solution, Strong SCHEMBL4940619 | 0.74 | IDO1 (0.94) | THRBIDO1MEN1KMT2AHDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6765003-B1 | ANTICARCINOGENIC, ANTITUMOR, AND ANTIMETASTASIS AGENTS; RHEUMATOID ARTHRITIS, OSTEOARTHRITIS, OSTEOPOROSIS, MULTIPLE SCLEROSIS, STROKE, ARTERIOSCLEROSIS, | PHARMACIA ITALIA, SPA (IT) | 2004-07-20 | — | — | US | disclosed |
| EP-1200398-A1 | 3-ARYLSULFONYL-2-(SUBSTITUTED METHYL)PROPANOIC ACID DERIVATES AS MATRIX METALLOPROTEINASE INHIBITORS | Pharmacia Italia S.p.A. (IT) | 2002-05-02 | — | — | EP | disclosed |
| WO-2001005756-A1 | 3-ARYLSULFONYL-2-(SUBSTITUTED METHYL)PROPANOIC ACID DERIVATES AS MATRIX METALLOPROTEINASE INHIBITORS | PHARMACIA & UPJOHN SPA (IT) | 2001-01-25 | — | — | WO | disclosed |