Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TK2 | O00142 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | ALB | P02768 | 2/20 | 0.38 |
| ▸ | BLM | P54132 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | TK1 | P04183 | 6/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7084531 | 0.90 | LMNA (0.40) | TK2LMNAALBBLMALDH1A1 | |
| SCHEMBL8003522 | 0.90 | LMNA (0.37) | TK2LMNAALBBLMALDH1A1 | |
| SCHEMBL7025003 | 0.88 | LMNA (0.39) | TK2LMNAALBBLMALDH1A1 | |
| SCHEMBL6663227 | 0.87 | TK1 (0.39) | TK2LMNAALBBLMALDH1A1 | |
| SCHEMBL27349255 | 0.78 | TK1 (0.42) | LMNAALBBLMALDH1A1POLB | |
| SCHEMBL18642515 | 0.77 | TK1 (0.46) | POLBTK1 | |
| SCHEMBL8053437 | 0.77 | TK1 (0.42) | TK2LMNAALBBLMALDH1A1 | |
| SCHEMBL8904559 | 0.76 | TK1 (0.43) | TK2LMNAALBBLMALDH1A1 | |
| SCHEMBL12658380 | 0.76 | TK1 (0.43) | TK2LMNAALBBLMALDH1A1 | |
| SCHEMBL1825757 | 0.76 | TK1 (0.43) | TK2LMNAALBBLMALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1490385-A2 | JAGGED 2 INHIBITORS FOR INDUCING APOPTOSIS | ISIS PHARMACEUTICALS, INC. (US) | 2004-12-29 | — | — | EP | disclosed |
| WO-2003077848-A2 | JAGGED 2 INHIBITORS FOR INDUCING APOPTOSIS | ISIS PHARMACEUTICALS, INC. (US) | 2003-09-25 | — | — | WO | disclosed |