(R)-Propiomazine

(R)-Propiomazine

SCHEMBL6910697

CCC(=O)c1ccc2c(c1)N(C[C@@H](C)N(C)C)c1ccccc1S2

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

HRH1

The experimentally established mechanism targets of (R)-Propiomazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HRH1 known ✓ P35367 2/20 1.00
CHRM2 P08172 6/20 1.00
HTR1A P08908 6/20 1.00
CHRM1 P11229 6/20 1.00
ADRA1A P35348 6/20 1.00
OPRM1 P35372 6/20 1.00
DRD3 P35462 6/20 1.00
KCNH2 Q12809 6/20 1.00
DRD2 P14416 3/20 1.00
ADRA2B P18089 2/20 1.00
ADRA2C P18825 2/20 1.00
CHRM3 P20309 2/20 1.00
HTR2A P28223 2/20 1.00
HTR2C P28335 2/20 1.00
OPRK1 P41145 2/20 1.00
HTR2B P41595 2/20 1.00
CYP2D6 P10635 7/20 0.66
CYP1A2 P05177 5/20 0.66
HSD17B10 Q99714 4/20 0.66
MTOR P42345 2/20 0.66

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Propiomazine SCHEMBL93770 1.00 CHRM2 (1.00) CHRM2HTR1ACHRM1ADRA1AOPRM1
Propiomazine SCHEMBL29370554 1.00 CHRM2 (1.00) CHRM2HTR1ACHRM1ADRA1AOPRM1
Propiomazine SCHEMBL29609596 1.00 CHRM2 (1.00) CHRM2HTR1ACHRM1ADRA1AOPRM1
Propiomazine SCHEMBL30903904 0.99 CHRM2 (0.98) CHRM2HTR1ACHRM1ADRA1AOPRM1
Propiomazine SCHEMBL141677 0.99 CHRM2 (0.98) CHRM2HTR1ACHRM1ADRA1AOPRM1
Propiomazine SCHEMBL6372719 0.99 CHRM2 (0.98) CHRM2HTR1ACHRM1ADRA1AOPRM1
Propiomazine SCHEMBL720224 0.98 CHRM2 (0.96) CHRM2HTR1ACHRM1ADRA1AOPRM1
Propiomazine SCHEMBL3863991 0.94 CHRM2 (0.88) CHRM2HTR1ACHRM1ADRA1AOPRM1
SCHEMBL10368273 0.88 CHRM2 (0.79) CHRM2HTR1ACHRM1ADRA1AOPRM1
Aceprometazine SCHEMBL142393 0.88 HTR1A (0.79) CHRM2HTR1ACHRM1ADRA1AOPRM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023213310-A1 CARBON CHAIN SUBSTANCE FOR REGULATING TRANSMEMBRANE TRANSPORT AND FLUIDITY OF CELL MEMBRANES, AND PREPARATION AND USE THEREOF 太阳雨林(北京)生物医药有限公司 2023-11-09 WO disclosed
WO-2023125184-A1 TERTIARY AMINE LIPID COMPOUND AND USE THEREOF 华南理工大学 2023-07-06 WO disclosed
EP-0988331-B1 METHOD FOR THE PREPARATION OF COPOLYMERS OF ETHYLENE/NORBORNENE-TYPE MONOMERS WITH CATIONIC PALLADIUM CATALYSTS PROMERUS LLC (US) 2004-09-01 EP disclosed
US-6265506-B1 AMORPHOUS COPOLYMERS THE B. F. GOODRICH COMPANY 2001-07-24 US disclosed
EP-0988331-A1 METHOD FOR THE PREPARATION OF COPOLYMERS OF ETHYLENE/NORBORNENE-TYPE MONOMERS WITH CATIONIC PALLADIUM CATALYSTS THE B.F. GOODRICH COMPANY (US) 2000-03-29 EP disclosed
WO-1998056839-A1 METHOD FOR THE PREPARATION OF COPOLYMERS OF ETHYLENE/NORBORNENE-TYPE MONOMERS WITH CATIONIC PALLADIUM CATALYSTS THE B.F. GOODRICH COMPANY (US) 1998-12-17 WO disclosed
US-5081205-A Preparation of cross-linked polycarbonate with cross-linker polycarbonate resin GENERAL ELECTRIC COMPANY (US) 1992-01-14 US disclosed
US-5064914-A By transesterification; high melt strength; extrusion, blow molding GENERAL ELECTRIC COMPANY (US) 1991-11-12 US disclosed
EP-0257321-B1 IMPROVING WEATHERABILITY AND ADHERENCE OF POLYPROPYLENE ADEKA ARGUS CHEMICAL CO., Ltd. (JP) 1991-03-13 EP disclosed
US-4999408-A Fireproofing GENERAL ELECTRIC COMPANY (US) 1991-03-12 US disclosed
US-4743688-A LIGHT STABILIZERS ADEKA ARGUS CHEMICAL CO., LTD. (JP) 1988-05-10 US disclosed
EP-0257321-A2 Improving weatherability and adherence of polypropylene ADEKA ARGUS CHEMICAL CO., Ltd. (JP) 1988-03-02 EP disclosed
US-4684680-A BENZOTRIAZOLYL PHENOL STABILIZER ADEKA ARGUS CHEMICAL CO., LTD. (JP) 1987-08-04 US disclosed
US-4681905-A 2,2,6,6-TETRAMETHYLPIPERIDYL COMPOUND, AND AN ALKYLIDENE-BIS-(BENZOTRIAZOLYL PHENYL) ADEKA ARGUS CHEMICAL CO., LTD. (JP) 1987-07-21 US disclosed
EP-0217149-A2 Poly(2,2,6,6-tetramethylpiperidylaminospiroglycolether-1,3,5-triazines) ADEKA ARGUS CHEMICAL CO., Ltd. (JP) 1987-04-08 EP disclosed
EP-0180992-A2 Stabilizer compositions for synthetic resins imparting improved light stability ADEKA ARGUS CHEMICAL CO., Ltd. (JP) 1986-05-14 EP disclosed
EP-0180991-A2 Thermosetting synthetic resin lacquer compositions having improved light stability ADEKA ARGUS CHEMICAL CO., Ltd. (JP) 1986-05-14 EP disclosed
EP-0180993-A2 Process for preparing 2,2'-methylene-bis-(4-hydrocarbyl-6-benzo-triazolylphenols) ADEKA ARGUS CHEMICAL CO., Ltd. (JP) 1986-05-14 EP disclosed
EP-0148962-A1 Bis(2,2,6,6-tetramethylpiperidyl-1,3,5-triazinyl)-spirodiamines and spiroglycol ethers and synthetic resin compositions containing the same ADEKA ARGUS CHEMICAL CO., Ltd. (JP) 1985-07-24 EP disclosed
US-4491643-A LIGHT STABILIZERS ADEKA ARGUS CHEMICAL CO., LTD. (JP) 1985-01-01 US disclosed