SCHEMBL6911227

SCHEMBL6911227

Cc1ccccc1NC1=CC([Si](C)(C)NC(C)(C)C)c2ccccc21

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 3/20 0.35
CCR4 P51679 1/20 0.35
MEN1 O00255 1/20 0.34
MAPK1 P28482 1/20 0.34
KMT2A Q03164 1/20 0.34
TDP1 Q9NUW8 1/20 0.34
L3MBTL1 Q9Y468 1/20 0.34
STAT3 P40763 1/20 0.33
MAPT P10636 1/20 0.33
HPGD P15428 2/20 0.33
TP53 P04637 2/20 0.33
SLC2A1 P11166 1/20 0.33
ALDH1A1 P00352 3/20 0.32
SMN1; SMN2 Q16637 2/20 0.32
KDM4E B2RXH2 1/20 0.32
MAPK10 P53779 1/20 0.32
HTT P42858 2/20 0.32
ADRA2A P08913 1/20 0.31
ADRA2B P18089 1/20 0.31
ADRA2C P18825 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7632634 0.79
SCHEMBL6906915 0.73 LMNA (0.37) LMNAMEN1MAPK1KMT2ATDP1
SCHEMBL6907806 0.72 GAA (0.31)
SCHEMBL6907559 0.72 GPR3 (0.33)
Hydrochloric Acid SCHEMBL7186892 0.70 GPR3 (0.31)
Hydrochloric Acid SCHEMBL6861887 0.70 GPR3 (0.31)
Hydrochloric Acid SCHEMBL6858902 0.70 GAA (0.30) LMNAMAPTHPGDHTT
Hydrochloric Acid SCHEMBL6861885 0.70 GPR3 (0.31)
Hydrochloric Acid SCHEMBL6851880 0.70 GAA (0.30)
Hydrochloric Acid SCHEMBL6851892 0.70 GAA (0.30)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0923589-B1 3-HETEROATOM SUBSTITUTED CYCLOPENTADIENYL-CONTAINING METAL COMPLEXES AND OLEFIN POLYMERIZATION PROCESS DOW GLOBAL TECHNOLOGIES INC (US) 2004-09-15 EP disclosed
US-6268444-B1 TITANIUM, ZIRCONIUM OR HAFNIUM COMPOUNDS FOR POLYMERIZATION DOW CHEMICAL COMPANY 2001-07-31 US disclosed