Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRAS | P01112 | 11/20 | 0.57 |
| ▸ | ESR1 | P03372 | 11/20 | 0.57 |
| ▸ | ESR2 | Q92731 | 11/20 | 0.57 |
| ▸ | TOP1 | P11387 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.56 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7127894 | 0.91 | HRAS (0.69) | HRASESR1ESR2TOP1KDM4E | |
| SCHEMBL7328867 | 0.84 | HRAS (0.54) | HRASESR1ESR2TOP1KDM4E | |
| SCHEMBL8917157 | 0.84 | HRAS (0.54) | HRASESR1ESR2TOP1KDM4E | |
| Hydrochloric Acid SCHEMBL6180839 | 0.83 | KDM4E (0.54) | HRASESR1ESR2TOP1KDM4E | |
| SCHEMBL7117804 | 0.81 | HRAS (0.48) | HRASESR1ESR2TOP1KDM4E | |
| SCHEMBL7127781 | 0.81 | HRAS (0.48) | HRASESR1ESR2TOP1KDM4E | |
| SCHEMBL7118414 | 0.81 | HRAS (0.48) | HRASESR1ESR2TOP1KDM4E | |
| SCHEMBL30644155 | 0.80 | HRAS (0.47) | HRASESR1ESR2TOP1KDM4E | |
| SCHEMBL6257041 | 0.80 | HRAS (0.47) | HRASESR1ESR2TOP1KDM4E | |
| Hydrochloric Acid SCHEMBL10425307 | 0.80 | TOP1 (0.48) | HRASESR1ESR2TOP1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040029810-A1 | Process for preparing distamycin derivatives | PHARMACIA ITALIA S.P.A. (IT) | 2004-02-12 | — | — | US | disclosed |
| EP-1311481-A1 | PROCESS FOR PREPARING DISTAMYCIN DERIVATIVES | Pharmacia Italia S.p.A. (IT) | 2003-05-21 | — | — | EP | disclosed |
| WO-2002008184-A1 | PROCESS FOR PREPARING DISTAMYCIN DERIVATIVES | PHARMACIA ITALIA S.P.A. (IT) | 2002-01-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040029810-A1 | Process for preparing distamycin derivatives | RPN2, DHPS, MYD88 | HRAS 293/4885ESR1 3897/4885ESR2 3101/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.