Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NMT2 | O60551 | 1/20 | 0.43 |
| ▸ | NMT1 | P30419 | 1/20 | 0.43 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.42 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.42 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.40 |
| ▸ | F2 | P00734 | 2/20 | 0.39 |
| ▸ | PLG | P00747 | 2/20 | 0.39 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.39 |
| ▸ | KDR | P35968 | 2/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | CDK4 | P11802 | 1/20 | 0.39 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.39 |
| ▸ | CCND1 | P24385 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | CCND3 | P30281 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6919545 | 0.90 | NMT2 (0.49) | NMT2NMT1PRMT5WDR77TRPA1 | |
| SCHEMBL6915290 | 0.84 | JAK2 (0.41) | PRMT5KDRCHEK1CDK4CCNA2 | |
| SCHEMBL6921256 | 0.76 | CDK2 (0.39) | CHEK1CDK2SMN1; SMN2MEN1KMT2A | |
| SCHEMBL6918858 | 0.76 | GPR3 (0.45) | KDRCHEK1LMNATSHRCYP1A2 | |
| SCHEMBL30896407 | 0.76 | GPR3 (0.45) | KDRCHEK1LMNATSHRCYP1A2 | |
| SCHEMBL29216861 | 0.74 | GPR3 (0.48) | NMT2NMT1PRMT5WDR77TRPA1 | |
| SCHEMBL6921370 | 0.73 | JAK2 (0.41) | PRMT5KDRCHEK1NPC1TSHR | |
| SCHEMBL6919278 | 0.67 | ENPP1 (0.43) | CDK4CCND1CDK2HPGDALOX15 | |
| SCHEMBL2945585 | 0.66 | MAPK14 (0.48) | PRMT5WDR77TRPA1F2PLG | |
| SCHEMBL6917877 | 0.66 | ERN1 (0.40) | CHEK1CDK4CCND1CDK2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004016615-A1 | PYRAZOLO (4,3c) CINNOLINE COMPOUNDS AS INHIBITORS OF ITK KINASE ACTIVITY | ASTRAZENECA AB (SE) | 2004-02-26 | — | — | WO | claimed |
| WO-2004016615-A1 | PYRAZOLO (4,3c) CINNOLINE COMPOUNDS AS INHIBITORS OF ITK KINASE ACTIVITY | ASTRAZENECA AB (SE) | 2004-02-26 | — | — | WO | disclosed |