Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 2/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.37 |
| ▸ | DHFR | P00374 | 1/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 4/20 | 0.36 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.35 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.35 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.35 |
| ▸ | CDK4 | P11802 | 1/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.35 |
| ▸ | CCND1 | P24385 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | CCND3 | P30281 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.35 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.35 |
| ▸ | GSK3B | P49841 | 2/20 | 0.34 |
| ▸ | GSK3A | P49840 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6921370 | 0.89 | JAK2 (0.41) | JAK2DYRK1ADYRK1BCHEK1MKNK1 | |
| SCHEMBL6921256 | 0.80 | CDK2 (0.39) | CHEK1ALKCDK2GSK3BGSK3A | |
| SCHEMBL6918858 | 0.80 | GPR3 (0.45) | DYRK1ADYRK1BCHEK1FGFR1KDR | |
| SCHEMBL30896407 | 0.80 | GPR3 (0.45) | DYRK1ADYRK1BCHEK1FGFR1KDR | |
| SCHEMBL6914017 | 0.73 | MAP4K4 (0.42) | CHEK1GSK3BLRRK2 | |
| SCHEMBL6919545 | 0.73 | NMT2 (0.49) | PRMT5CDK2KDRGSK3B | |
| SCHEMBL6920030 | 0.70 | DYRK1A (0.53) | DYRK1ADYRK1BCHEK1FGFR1 | |
| SCHEMBL6917877 | 0.69 | ERN1 (0.40) | CHEK1ALKCDK4CCND1CDK2 | |
| SCHEMBL29216870 | 0.69 | GPR3 (0.58) | JAK2DHFRALKALOX5LRRK2 | |
| SCHEMBL28953289 | 0.65 | PRMT5 (0.49) | JAK2DYRK1ADYRK1BDHFRCHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004016615-A1 | PYRAZOLO (4,3c) CINNOLINE COMPOUNDS AS INHIBITORS OF ITK KINASE ACTIVITY | ASTRAZENECA AB (SE) | 2004-02-26 | — | — | WO | claimed |
| WO-2004016615-A1 | PYRAZOLO (4,3c) CINNOLINE COMPOUNDS AS INHIBITORS OF ITK KINASE ACTIVITY | ASTRAZENECA AB (SE) | 2004-02-26 | — | — | WO | disclosed |