Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 2/20 | 0.53 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.53 |
| ▸ | PPARA | Q07869 | 7/20 | 0.52 |
| ▸ | PPARG | P37231 | 6/20 | 0.52 |
| ▸ | ITGA4 | P13612 | 2/20 | 0.48 |
| ▸ | ITGB7 | P26010 | 2/20 | 0.48 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.48 |
| ▸ | ACE | P12821 | 1/20 | 0.47 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.43 |
| ▸ | PPARD | Q03181 | 2/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | CTSS | P25774 | 3/20 | 0.41 |
| ▸ | CTSK | P43235 | 2/20 | 0.41 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.41 |
| ▸ | ITGAV | P06756 | 1/20 | 0.41 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.41 |
| ▸ | CTSL | P07711 | 1/20 | 0.41 |
| ▸ | CTSB | P07858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23963236 | 0.91 | PPARG (0.44) | ITGB3ITGA2BPPARAPPARGITGA4 | |
| SCHEMBL23963101 | 0.91 | PPARG (0.44) | ITGB3ITGA2BPPARAPPARGITGA4 | |
| SCHEMBL12158621 | 0.87 | ITGB3 (0.58) | ITGB3ITGA2BPPARAPPARGITGA4 | |
| SCHEMBL12158601 | 0.87 | ITGB3 (0.58) | ITGB3ITGA2BPPARAPPARGITGA4 | |
| SCHEMBL1350409 | 0.85 | PTPN1 (0.57) | ITGB3ITGA2BPPARAPPARGPTPN1 | |
| SCHEMBL1350878 | 0.85 | PTPN1 (0.57) | ITGB3ITGA2BPPARAPPARGPTPN1 | |
| SCHEMBL11915445 | 0.85 | PPARA (0.50) | ITGB3ITGA2BPPARAPPARGITGA4 | |
| SCHEMBL4196625 | 0.85 | CTSS (0.49) | ITGB3ITGA2BPPARAPPARGITGA4 | |
| SCHEMBL20422453 | 0.85 | CTSS (0.49) | ITGB3ITGA2BPPARAPPARGITGA4 | |
| SCHEMBL11915449 | 0.85 | PPARA (0.50) | ITGB3ITGA2BPPARAPPARGITGA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6825200-B1 | TREATING, PROLONGING, OR EXTENDING THE ONSET OF ORGAN REJECTION IN A HUMAN DURING OR AFTER ORGAN TRANSPLANTATION IN A HUMAN | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2004-11-30 | — | — | US | disclosed |
| EP-1226159-A1 | SUBSTITUTED DIPEPTIDES HAVING NOS INHIBITING ACTIVITY | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-07-31 | — | — | EP | disclosed |
| WO-2001032690-A1 | SUBSTITUTED DIPEPTIDES HAVING NOS INHIBITING ACTIVITY | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-05-10 | — | — | WO | disclosed |