Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 3/20 | 0.53 |
| ▸ | DYRK1B | Q9Y463 | 3/20 | 0.53 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.52 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.52 |
| ▸ | NEK2 | P51955 | 1/20 | 0.52 |
| ▸ | MAPK15 | Q8TD08 | 1/20 | 0.52 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.47 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.47 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | PLK4 | O00444 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6919087 | 0.91 | HSD17B1 (0.50) | DYRK1ADYRK1BCHEK1FGFR1NEK2 | |
| SCHEMBL6919545 | 0.73 | NMT2 (0.49) | MAP4K4MAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL29930674 | 0.71 | DYRK1A (0.71) | DYRK1ADYRK1BCHEK1FGFR1NEK2 | |
| SCHEMBL12907242 | 0.71 | MAP4K4 (0.61) | DYRK1ADYRK1BCHEK1FGFR1NEK2 | |
| SCHEMBL6914017 | 0.71 | MAP4K4 (0.42) | CHEK1MAP4K4 | |
| SCHEMBL12907599 | 0.71 | CHEK1 (0.59) | DYRK1ADYRK1BCHEK1FGFR1NEK2 | |
| SCHEMBL6915290 | 0.70 | JAK2 (0.41) | DYRK1ADYRK1BCHEK1FGFR1 | |
| SCHEMBL12821681 | 0.69 | CHEK1 (0.69) | DYRK1ADYRK1BCHEK1FGFR1NEK2 | |
| SCHEMBL3926376 | 0.69 | HSD17B1 (0.57) | MAP4K4MAPTHSD17B1HSD17B2MEN1 | |
| SCHEMBL29963134 | 0.68 | CHEK1 (1.00) | DYRK1ADYRK1BCHEK1FGFR1NEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004016615-A1 | PYRAZOLO (4,3c) CINNOLINE COMPOUNDS AS INHIBITORS OF ITK KINASE ACTIVITY | ASTRAZENECA AB (SE) | 2004-02-26 | — | — | WO | claimed |
| WO-2004016615-A1 | PYRAZOLO (4,3c) CINNOLINE COMPOUNDS AS INHIBITORS OF ITK KINASE ACTIVITY | ASTRAZENECA AB (SE) | 2004-02-26 | — | — | WO | disclosed |