Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | BLM | P54132 | 1/20 | 0.56 |
| ▸ | AGER | Q15109 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | MYC | P01106 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | NAPRT | Q6XQN6 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16790442 | 0.87 | ALDH1A1 (0.57) | TSHRKDM4EALDH1A1ALOX15NPSR1 | |
| SCHEMBL31037820 | 0.83 | KDM4E (0.61) | TSHRKDM4EALDH1A1ALOX15NPSR1 | |
| SCHEMBL4914014 | 0.83 | KDM4E (0.61) | TSHRKDM4EALDH1A1ALOX15NPSR1 | |
| SCHEMBL1104042 | 0.81 | KDM4E (0.48) | TSHRKDM4EALDH1A1ALOX15NPSR1 | |
| SCHEMBL29559479 | 0.81 | KDM4E (0.67) | TSHRKDM4EALDH1A1ALOX15NPSR1 | |
| SCHEMBL519094 | 0.81 | KDM4E (0.67) | TSHRKDM4EALDH1A1ALOX15NPSR1 | |
| SCHEMBL1505205 | 0.78 | KDM4E (0.50) | TSHRKDM4EALDH1A1ALOX15NPSR1 | |
| SCHEMBL2749775 | 0.78 | KDM4E (0.50) | TSHRKDM4EALDH1A1ALOX15NPSR1 | |
| SCHEMBL186286 | 0.78 | TSHR (0.86) | TSHRKDM4EALDH1A1ALOX15CYP3A4 | |
| SCHEMBL311087 | 0.77 | KDM4E (0.71) | TSHRKDM4EALDH1A1ALOX15NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004075893-A1 | METHOD OF TREATMENT OF CARDIAC AND/OR RENAL FAILURE USING A CALCIUM CHANNEL BLOCKER AND AN ANGIOTENSIN CONVERTING ENZYME INHIBITOR OR AN ANGIOTENSIN II RECEPTOR BLOCKER | DIAKRON PHARMACEUTICALS, INC. (US) | 2004-09-10 | — | — | WO | claimed |