Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 9/20 | 0.63 |
| ▸ | MMP9 | P14780 | 8/20 | 0.63 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | HTT | P42858 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.56 |
| ▸ | MMP1 | P03956 | 1/20 | 0.56 |
| ▸ | MMP3 | P08254 | 1/20 | 0.56 |
| ▸ | MMP7 | P09237 | 1/20 | 0.56 |
| ▸ | MMP13 | P45452 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11952564 | 0.84 | MMP2 (0.62) | MMP2MMP9ADAMTS4ALDH1A1MAPT | |
| SCHEMBL5502394 | 0.84 | POLB (0.66) | MMP2MMP9ADAMTS4ALDH1A1MAPT | |
| SCHEMBL11950557 | 0.84 | MMP2 (0.62) | MMP2MMP9ADAMTS4ALDH1A1MAPT | |
| SCHEMBL6522675 | 0.84 | MMP2 (0.66) | MMP2MMP9ADAMTS4ALDH1A1MAPT | |
| SCHEMBL6670956 | 0.84 | POLB (0.66) | MMP2MMP9ADAMTS4ALDH1A1MAPT | |
| SCHEMBL8086539 | 0.82 | ALDH1A1 (0.67) | MMP2MMP9ADAMTS4ALDH1A1MAPT | |
| SCHEMBL27146771 | 0.82 | MMP2 (0.59) | MMP2MMP9ADAMTS4ALDH1A1MAPT | |
| SCHEMBL27146770 | 0.82 | MMP2 (0.59) | MMP2MMP9ADAMTS4ALDH1A1MAPT | |
| SCHEMBL14398402 | 0.82 | MMP2 (0.59) | MMP2MMP9ADAMTS4ALDH1A1MAPT | |
| SCHEMBL4188026 | 0.81 | MMP2 (0.85) | MMP2MMP9ADAMTS4ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6720315-B2 | FOR INHIBITING BONE RESORPTION, PERIODONTAL DISEASE, OSTEOPOROSIS, HUMORAL HYPERCALCEMIA OF MALIGNANCY, PAGET'S DISEASE, TUMOR METASTASIS, SOLID TUMOR GROWTH, ANGIOGENESIS, MACULAR DEGENERATION AND DIABETIC RETINOPATHY RETINOPATHY | PHARMACIA CORPORATION | 2004-04-13 | — | — | US | disclosed |