Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.67 |
| ▸ | MAPT | P10636 | 1/20 | 0.67 |
| ▸ | MMP2 | P08253 | 9/20 | 0.59 |
| ▸ | MMP9 | P14780 | 8/20 | 0.59 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 2/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.53 |
| ▸ | MMP1 | P03956 | 1/20 | 0.53 |
| ▸ | MMP3 | P08254 | 1/20 | 0.53 |
| ▸ | MMP7 | P09237 | 1/20 | 0.53 |
| ▸ | MMP13 | P45452 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5502394 | 0.83 | POLB (0.66) | ALDH1A1MAPTMMP2MMP9ADAMTS4 | |
| SCHEMBL6670956 | 0.83 | POLB (0.66) | ALDH1A1MAPTMMP2MMP9ADAMTS4 | |
| SCHEMBL11589175 | 0.83 | MMP9 (0.46) | ALDH1A1MAPTMMP2MMP9ADAMTS4 | |
| SCHEMBL6916882 | 0.82 | MMP2 (0.63) | ALDH1A1MAPTMMP2MMP9ADAMTS4 | |
| SCHEMBL11952564 | 0.81 | MMP2 (0.62) | ALDH1A1MAPTMMP2MMP9ADAMTS4 | |
| SCHEMBL11950557 | 0.81 | MMP2 (0.62) | ALDH1A1MAPTMMP2MMP9ADAMTS4 | |
| SCHEMBL6522675 | 0.81 | MMP2 (0.66) | ALDH1A1MAPTMMP2MMP9ADAMTS4 | |
| SCHEMBL31086837 | 0.80 | ALDH1A1 (1.00) | ALDH1A1MAPTMMP2MMP9ADAMTS4 | |
| SCHEMBL698062 | 0.79 | MMP2 (0.63) | ALDH1A1MAPTMMP2MMP9ADAMTS4 | |
| SCHEMBL698061 | 0.79 | MMP2 (0.63) | ALDH1A1MAPTMMP2MMP9ADAMTS4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0817795-B1 | NOVEL 4-SUBSTITUTED-3-PEPTIDYL-AZETIDIN-2-ONE DERIVATIVES USEFUL AS CYSTEINE PROTEINASE INHIBITOR | NAEJA PHARMACEUTICAL INC (CA) | 2000-11-15 | — | — | EP | claimed |
| US-5986108-A | ENZYME INHIBITORS | SYNPHAR LABORATORIES, INC. (CA) | 1999-11-16 | — | — | US | claimed |