Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Trolamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.37 |
| ▸ | KDM4A | O75164 | 1/20 | 0.37 |
| ▸ | PHF8 | Q9UPP1 | 1/20 | 0.37 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.34 |
| ▸ | FDPS | P14324 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | GGPS1 | O95749 | 3/20 | 0.32 |
| ▸ | LAP3 | P28838 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
| ▸ | SMPD1 | P17405 | 3/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trolamine SCHEMBL28401664 | 1.00 | KDM4C (0.37) | KDM4CKDM4APHF8KDM2APTPN1 | |
| Phosphoric Acid SCHEMBL28350800 | 0.88 | FDPS (0.40) | KDM4CPTPN1FDPSLMNALAP3 | |
| Phosphoric Acid SCHEMBL1176955 | 0.88 | FDPS (0.40) | KDM4CPTPN1FDPSLMNALAP3 | |
| Phosphoric Acid SCHEMBL27702165 | 0.88 | FDPS (0.40) | KDM4CPTPN1FDPSLMNALAP3 | |
| Phosphoric Acid SCHEMBL29466464 | 0.86 | FDPS (0.39) | KDM4CPTPN1FDPSLMNALAP3 | |
| Phosphoric Acid SCHEMBL28156330 | 0.86 | FDPS (0.39) | KDM4CPTPN1FDPSLMNALAP3 | |
| Phosphoric Acid SCHEMBL28067057 | 0.84 | KDM4C (0.41) | KDM4CKDM4APHF8KDM2AFDPS | |
| SCHEMBL15563205 | 0.82 | LMNA (0.39) | KDM4CKDM4APHF8KDM2ALMNA | |
| SCHEMBL7759645 | 0.82 | LMNA (0.39) | KDM4CKDM4APHF8KDM2ALMNA | |
| SCHEMBL31365935 | 0.82 | LMNA (0.39) | KDM4CKDM4APHF8KDM2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107049957-A | The nano particle of encapsulating is prepared plant-scale | 伊休蒂卡有限公司 | 2017-08-18 | — | — | CN | claimed |
| CN-106727424-A | The novel form of Diclofenac | 伊休蒂卡有限公司 | 2017-05-31 | — | — | CN | claimed |
| CN-106727477-A | The novel form of Diclofenac | 伊休蒂卡有限公司 | 2017-05-31 | — | — | CN | claimed |
| CN-105663045-A | Production of encapsulated nanoparticles at high volume fractions | 伊休蒂卡有限公司 | 2016-06-15 | — | — | CN | claimed |
| EP-2421509-A1 | PRODUCTION OF ENCAPSULATED NANOPARTICLES AT HIGH VOLUME FRACTIONS | Iceutica Pty Ltd. (AU) | 2012-02-29 | — | — | EP | claimed |
| WO-2010121320-A1 | PRODUCTION OF ENCAPSULATED NANOPARTICLES AT HIGH VOLUME FRACTIONS | ICEUTICA PTY LTD (AU) | 2010-10-28 | — | — | WO | claimed |
| CN-110604721-B | Abiraterone acetate preparation | 太阳药业环球公司 | 2022-02-08 | — | — | CN | disclosed |
| CN-104000785-B | Novel dosage forms of metaxalone | 伊休蒂卡有限公司 | 2021-01-05 | — | — | CN | disclosed |
| CN-105431136-B | Metaxalone formulations | 冰由提卡公司 | 2020-03-24 | — | — | CN | disclosed |
| CN-110604721-A | Abiraterone acetate preparation | 太阳药业环球公司 | 2019-12-24 | — | — | CN | disclosed |
| CN-105246598-B | Abiraterone acetate preparation | 太阳药业环球公司 | 2019-09-13 | — | — | CN | disclosed |
| CN-107049957-A | The nano particle of encapsulating is prepared plant-scale | 伊休蒂卡有限公司 | 2017-08-18 | — | — | CN | disclosed |
| CN-107073010-A | New meloxicam formulations | 伊休蒂卡有限公司 | 2017-08-18 | — | — | CN | disclosed |
| CN-106727424-A | The novel form of Diclofenac | 伊休蒂卡有限公司 | 2017-05-31 | — | — | CN | disclosed |
| CN-106727477-A | The novel form of Diclofenac | 伊休蒂卡有限公司 | 2017-05-31 | — | — | CN | disclosed |
| CN-106687112-A | Abiraterone acetate formulation and methods of use | 冰由提卡公司 | 2017-05-17 | — | — | CN | disclosed |
| CN-105663045-A | Production of encapsulated nanoparticles at high volume fractions | 伊休蒂卡有限公司 | 2016-06-15 | — | — | CN | disclosed |
| CN-105246598-A | Abiraterone acetate preparation | ICEUTICA INC | 2016-01-13 | — | — | CN | disclosed |