Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 10/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.47 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.47 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 5/20 | 0.42 |
| ▸ | RAB9A | P51151 | 5/20 | 0.42 |
| ▸ | PKM | P14618 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | NSD2 | O96028 | 2/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6808731 | 0.91 | TGFBR1 (0.44) | TGFBR1MAPK14RIPK2ACVR1BTDP1 | |
| SCHEMBL15984797 | 0.79 | NPC1 (0.57) | TGFBR1MAPK14RIPK2ACVR1BTDP1 | |
| SCHEMBL2044546 | 0.76 | TGFBR1 (0.53) | TGFBR1MAPK14RIPK2ACVR1BTDP1 | |
| SCHEMBL6601316 | 0.73 | TGFBR1 (0.50) | TGFBR1MAPK14RIPK2ACVR1BTDP1 | |
| SCHEMBL15849494 | 0.71 | TGFBR1 (0.62) | TGFBR1MAPK14RIPK2ACVR1BTDP1 | |
| SCHEMBL5139229 | 0.71 | TGFBR1 (0.47) | TGFBR1MAPK14RIPK2ACVR1BTDP1 | |
| SCHEMBL14576854 | 0.70 | TGFBR1 (0.68) | TGFBR1MAPK14RIPK2ACVR1BTDP1 | |
| SCHEMBL4863284 | 0.70 | KDM4E (0.64) | TGFBR1MAPK14RIPK2ACVR1BTDP1 | |
| SCHEMBL4864372 | 0.70 | GAA (0.53) | TGFBR1MAPK14RIPK2ACVR1BTDP1 | |
| SCHEMBL8819232 | 0.70 | TGFBR1 (0.55) | TGFBR1MAPK14RIPK2ACVR1BTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040039198-A1 | Compounds | SMITHKLINE BEECHAM CORPORATION | 2004-02-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040039198-A1 | Compounds | SMAD3, SMAD2, TGFBR1 | TGFBR1 3/4885MAPK14 255/4885RIPK2 282/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.