Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 6/20 | 0.55 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.44 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.44 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 7/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 7/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 6/20 | 0.44 |
| ▸ | USP2 | O75604 | 5/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.44 |
| ▸ | MEN1 | O00255 | 5/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 3/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8816383 | 0.91 | TGFBR1 (0.66) | TGFBR1MAPK14RIPK2ACVR1BTDP1 | |
| SCHEMBL8818164 | 0.87 | TGFBR1 (0.50) | TGFBR1MAPK14RIPK2ACVR1BTDP1 | |
| SCHEMBL8815687 | 0.80 | TGFBR1 (0.49) | TGFBR1MAPK14CYP1A2MEN1KMT2A | |
| SCHEMBL8819429 | 0.79 | TGFBR1 (0.48) | TGFBR1MAPK14MEN1KMT2A | |
| SCHEMBL6120916 | 0.78 | TGFBR1 (0.54) | TGFBR1MAPK14MEN1KMT2AALDH1A1 | |
| SCHEMBL8814729 | 0.78 | NR1I3 (0.54) | TGFBR1MAPK14MEN1KMT2ALMNA | |
| SCHEMBL8817137 | 0.77 | TGFBR1 (0.54) | TGFBR1MAPK14MEN1KMT2AALDH1A1 | |
| SCHEMBL8816391 | 0.77 | ALDH1A1 (0.56) | TGFBR1MAPK14TDP1CYP1A2MEN1 | |
| SCHEMBL8818425 | 0.77 | TGFBR1 (0.46) | TGFBR1MAPK14LMNAALDH1A1KDM4E | |
| SCHEMBL8816897 | 0.77 | TGFBR1 (0.46) | TGFBR1MAPK14MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012066122-A1 | 2 - (PYRIDIN- 2 -YL) -QUINAZOLINE DERIVATIVES AND THEIR USE AS MICROBICIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2012-05-24 | — | — | WO | disclosed |