Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | CDK1 | P06493 | 1/20 | 0.43 |
| ▸ | CSF1R | P07333 | 1/20 | 0.43 |
| ▸ | PRKACA | P17612 | 1/20 | 0.43 |
| ▸ | FLT1 | P17948 | 1/20 | 0.43 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6920062 | 1.00 | ALDH1A1 (0.50) | ALDH1A1LMNASMN1; SMN2HDAC1HDAC6 | |
| SCHEMBL6919642 | 0.85 | ALDH1A1 (0.50) | ALDH1A1LMNASMN1; SMN2HDAC1HDAC6 | |
| SCHEMBL15771457 | 0.84 | ALDH1A1 (0.54) | ALDH1A1LMNAHDAC1HDAC6NPC1 | |
| SCHEMBL15771458 | 0.84 | ALDH1A1 (0.54) | ALDH1A1LMNAHDAC1HDAC6NPC1 | |
| SCHEMBL6918497 | 0.81 | HDAC6 (0.41) | LMNAHDAC1HDAC6HDAC8HDAC3 | |
| SCHEMBL2407415 | 0.79 | SMN1; SMN2 (0.77) | ALDH1A1LMNASMN1; SMN2HDAC1HDAC6 | |
| SCHEMBL6918744 | 0.78 | ROCK2 (0.47) | ALDH1A1HDAC1HDAC6HDAC8KMT2A | |
| SCHEMBL6918437 | 0.76 | EGFR (0.58) | ALDH1A1LMNASMN1; SMN2HDAC6NPC1 | |
| SCHEMBL2413088 | 0.75 | ROCK2 (0.68) | ALDH1A1LMNASMN1; SMN2HDAC1HDAC6 | |
| SCHEMBL12376697 | 0.75 | KDM4E (0.49) | LMNANPC1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011106632-A1 | SUBSTITUTED HYDROXAMIC ACIDS AND USES THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2011-09-01 | — | — | WO | disclosed |