⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9794154 | 0.85 | — | — | |
| SCHEMBL14560468 | 0.76 | — | — | |
| SCHEMBL15810776 | 0.73 | — | — | |
| SCHEMBL31432779 | 0.73 | TSHR (0.41) | — | |
| SCHEMBL8278 | 0.69 | — | — | |
| SCHEMBL5609364 | 0.67 | — | — | |
| Hydrochloric Acid SCHEMBL16047936 | 0.67 | — | — | |
| SCHEMBL28477 | 0.67 | — | — | |
| SCHEMBL15093993 | 0.66 | ALDH1A1 (0.30) | — | |
| SCHEMBL31222804 | 0.66 | ALDH1A1 (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220000883-A1 | PROSTAGLANDIN RECEPTOR EP2 ANTAGONISTS, DERIVATIVES, COMPOSITIONS, AND USES RELATED THERETO | EMORY UNIVERSITY | 2022-01-06 | — | — | US | disclosed |
| CN-109563323-B | Polypropylene-based resin composition | LG化学株式会社 | 2021-12-03 | — | — | CN | disclosed |
| US-11077120-B2 | Prostaglandin receptor EP2 antagonists, derivatives, compositions, and uses related thereto | EMORY UNIVERSITY (US) | 2021-08-03 | — | — | US | disclosed |
| CN-108329443-B | high-Florichaugs parameter block polymer and random polymer for oriented self-assembly, and preparation method and self-assembly method thereof | 北京科华微电子材料有限公司 | 2020-10-09 | — | — | CN | disclosed |
| EP-3137074-B1 | PROSTAGLANDIN RECEPTOR EP2 ANTAGONISTS, DERIVATIVES, COMPOSITIONS, AND USES RELATED THERETO | UNIV EMORY (US) | 2020-08-05 | — | — | EP | disclosed |
| US-20200085837-A1 | Prostaglandin Receptor EP2 Antagonists, Derivatives, Compositions, and Uses Related Thereto | UNIV EMORY (US) | 2020-03-19 | — | — | US | disclosed |
| US-10568889-B2 | Prostaglandin receptor EP2 antagonists, derivatives, compositions, and uses related thereto | EMORY UNIVERSITY (US) | 2020-02-25 | — | — | US | disclosed |
| US-20180318315-A1 | Prostaglandin Receptor EP2 Antagonists, Derivatives, Compositions, and Uses Related Thereto | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2018-11-08 | — | — | US | disclosed |
| US-10052332-B2 | Prostaglandin receptor EP2 antagonists, derivatives, compositions, and uses related thereto | EMORY UNIVERSITY (US) | 2018-08-21 | — | — | US | disclosed |
| EP-3137074-A1 | PROSTAGLANDIN RECEPTOR EP2 ANTAGONISTS, DERIVATIVES, COMPOSITIONS, AND USES RELATED THERETO | Emory University (US) | 2017-03-08 | — | — | EP | disclosed |
| WO-1991003474-A1 | HYPOGLYCEMIC THIAZOLIDINEDIONE DERIVATIVES | PFIZER INC. (US) | 1991-03-21 | — | — | WO | disclosed |
| US-4983627-A | Treating atherosclerosis, thrombosis and vasospasms; anticholesterol,-secretory,-ulcer and hypotensive agents | SYNTEX (U.S.A.) INC. (US) | 1991-01-08 | — | — | US | disclosed |
| EP-0378318-A1 | Process for synthesis of FK-506 and tricarbonyl intermediates | MERCK & CO. INC. (US) | 1990-07-18 | — | — | EP | disclosed |
| EP-0332332-A1 | Hypoglycemic thiazolidinedione derivatives | PFIZER INC. (US) | 1989-09-13 | — | — | EP | disclosed |
| US-4525586-A | Composition and process | THE UPJOHN COMPANY (US) | 1985-06-25 | — | — | US | disclosed |
| US-4420632-A | PROSTAGLANDINS; ANTICOAGULANTS | THE UPJOHN COMPANY (US) | 1983-12-13 | — | — | US | disclosed |
| US-4418206-A | 9-Deoxy-9-methylene derivatives of (dl)-16-phenoxy and 16-phenoxy substituted prostatriene compounds | SYNTEX (U.S.A.) INC. (US) | 1983-11-29 | — | — | US | disclosed |
| US-4349689-A | Methano carbacyclin analogs | THE UPJOHN COMPANY (US) | 1982-09-14 | — | — | US | disclosed |
| US-4306075-A | Composition and process | THE UPJOHN COMPANY (US) | 1981-12-15 | — | — | US | disclosed |
| US-4306076-A | Inter-phenylene CBA compounds | THE UPJOHN COMPANY (US) | 1981-12-15 | — | — | US | disclosed |