Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 4/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8004084 | 0.89 | OPRD1 (0.37) | CYP1A2CYP3A4OPRM1OPRK1OPRD1 | |
| SCHEMBL7993545 | 0.88 | CYP3A4 (0.54) | CYP1A2CYP3A4OPRM1OPRK1OPRD1 | |
| SCHEMBL4591245 | 0.88 | CYP3A4 (0.54) | CYP1A2CYP3A4OPRM1OPRK1OPRD1 | |
| SCHEMBL8009424 | 0.88 | CYP3A4 (0.54) | CYP1A2CYP3A4OPRM1OPRK1OPRD1 | |
| SCHEMBL8002856 | 0.88 | CYP3A4 (0.54) | CYP1A2CYP3A4OPRM1OPRK1OPRD1 | |
| SCHEMBL5311342 | 0.82 | OPRD1 (0.40) | CYP1A2CYP3A4OPRM1OPRK1OPRD1 | |
| SCHEMBL4575462 | 0.82 | OPRD1 (0.40) | CYP1A2CYP3A4OPRM1OPRK1OPRD1 | |
| SCHEMBL8145779 | 0.82 | OPRD1 (0.40) | CYP1A2CYP3A4OPRM1OPRK1OPRD1 | |
| SCHEMBL6246739 | 0.72 | HSP90AA1 (0.56) | CYP1A2HPGD | |
| SCHEMBL4599120 | 0.71 | OPRD1 (0.44) | OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1003373-A4 | COMPOSITIONS AND METHODS FOR REDUCING RESPIRATORY DEPRESSION AND ATTENDANT SIDE EFFECTS OF MU OPIOID COMPOUNDS | DELTA PHARMACEUTICALS INC (US) | 2000-09-20 | — | — | EP | claimed |
| EP-1003373-A1 | COMPOSITIONS AND METHODS FOR REDUCING RESPIRATORY DEPRESSION AND ATTENDANT SIDE EFFECTS OF MU OPIOID COMPOUNDS | DELTA PHARMACEUTICALS, INC. (US) | 2000-05-31 | — | — | EP | claimed |
| WO-1999001033-A1 | COMPOSITIONS AND METHODS FOR REDUCING RESPIRATORY DEPRESSION AND ATTENDANT SIDE EFFECTS OF MU OPIOID COMPOUNDS | DELTA PHARMACEUTICALS, INC. (US) | 1999-01-14 | — | — | WO | claimed |
| WO-2003057223-A9 | METHOD OF TREATING SEXUAL DYSFUNCTIONS WITH DELTA OPIOID RECEPTOR AGONIST COMPOUNDS | ARDENT PHARMACEUTICALS INC (US) | 2004-04-29 | — | — | WO | disclosed |
| EP-1003373-A4 | COMPOSITIONS AND METHODS FOR REDUCING RESPIRATORY DEPRESSION AND ATTENDANT SIDE EFFECTS OF MU OPIOID COMPOUNDS | DELTA PHARMACEUTICALS INC (US) | 2000-09-20 | — | — | EP | disclosed |
| EP-0938317-A4 | COMPOSITIONS AND METHODS FOR REDUCING RESPIRATORY DEPRESSION | DELTA PHARMACEUTICALS INC (US) | 2000-08-23 | — | — | EP | disclosed |
| EP-1003373-A1 | COMPOSITIONS AND METHODS FOR REDUCING RESPIRATORY DEPRESSION AND ATTENDANT SIDE EFFECTS OF MU OPIOID COMPOUNDS | DELTA PHARMACEUTICALS, INC. (US) | 2000-05-31 | — | — | EP | disclosed |
| EP-0938317-A1 | COMPOSITIONS AND METHODS FOR REDUCING RESPIRATORY DEPRESSION | DELTA PHARMACEUTICALS, INC. (US) | 1999-09-01 | — | — | EP | disclosed |
| WO-1999001033-A1 | COMPOSITIONS AND METHODS FOR REDUCING RESPIRATORY DEPRESSION AND ATTENDANT SIDE EFFECTS OF MU OPIOID COMPOUNDS | DELTA PHARMACEUTICALS, INC. (US) | 1999-01-14 | — | — | WO | disclosed |
| WO-1997046240-A1 | COMPOSITIONS AND METHODS FOR REDUCING RESPIRATORY DEPRESSION | DELTA PHARMACEUTICALS, INC. (US) | 1997-12-11 | — | — | WO | disclosed |