Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 7/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5311342 | 1.00 | OPRD1 (0.40) | OPRD1OPRM1HSP90AA1HSP90AB1OPRK1 | |
| SCHEMBL4575462 | 1.00 | OPRD1 (0.40) | OPRD1OPRM1HSP90AA1HSP90AB1OPRK1 | |
| SCHEMBL8004084 | 0.84 | OPRD1 (0.37) | OPRD1OPRM1HSP90AA1HSP90AB1OPRK1 | |
| SCHEMBL6918646 | 0.82 | CYP1A2 (0.47) | OPRD1OPRM1OPRK1HPGDCYP1A2 | |
| SCHEMBL6937908 | 0.82 | GAA (0.35) | OPRD1HPGDALDH1A1MAPT | |
| SCHEMBL7993545 | 0.80 | CYP3A4 (0.54) | OPRD1OPRM1OPRK1HPGDCYP1A2 | |
| SCHEMBL8009424 | 0.80 | CYP3A4 (0.54) | OPRD1OPRM1OPRK1HPGDCYP1A2 | |
| SCHEMBL4591245 | 0.80 | CYP3A4 (0.54) | OPRD1OPRM1OPRK1HPGDCYP1A2 | |
| SCHEMBL8002856 | 0.80 | CYP3A4 (0.54) | OPRD1OPRM1OPRK1HPGDCYP1A2 | |
| SCHEMBL6246739 | 0.75 | HSP90AA1 (0.56) | HSP90AA1HSP90AB1HPGDCYP1A2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0938317-A4 | COMPOSITIONS AND METHODS FOR REDUCING RESPIRATORY DEPRESSION | DELTA PHARMACEUTICALS INC (US) | 2000-08-23 | — | — | EP | claimed |
| EP-0938317-A1 | COMPOSITIONS AND METHODS FOR REDUCING RESPIRATORY DEPRESSION | DELTA PHARMACEUTICALS, INC. (US) | 1999-09-01 | — | — | EP | claimed |
| WO-1997046240-A1 | COMPOSITIONS AND METHODS FOR REDUCING RESPIRATORY DEPRESSION | DELTA PHARMACEUTICALS, INC. (US) | 1997-12-11 | — | — | WO | claimed |